ISO9001:2000 Certified
Material Safety Data Sheet
8-Hydroxyquinoline
Section 1 - Chemical Product and Company Identification
MSDS Name:
8-Hydroxyquinoline
Catalog Numbers:
LC15575
Synonyms:
8-Oxyquinoline; Oxybenzopyridine; Hydroxybenzopyridine; Phenopyridine; 8-Quinol; 8-
Quinolinol.
Company Identification:
LabChem Inc
200 William Pitt Way
Pittsburgh, PA 15238
Company Phone Number:
(412) 826-5230
Emergency Phone Number:
(800) 424-9300
CHEMTREC Phone Number:
(800) 424-9300
Section 2 ?Composition, Information on Ingredients
CAS# Chemical Name: Percent
148-24-3 8-Hydroxyquinoline 100
Section 3 - Hazards Identification
Emergency Overview
Appearance: Slightly beige flakes.
Danger! Causes eye, skin, and respiratory tract irritation. Harmful if swallowed. Possible risks of
irreversible effects.
Target Organs: Respiratory system, eyes, skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Based on studies with laboratory animals, oral doses may cause anorexia, malaise, confusion,
respiratory difficulty, paralysis, and other CNS effects.
Inhalation:
Dust is irritating to the respiratory tract. Symptoms may include coughing, labored breathing and
chest pain. Other health effects may parallel those from ingestion.
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Material Safety Data Sheet
8-Hydroxyquinoline
Chronic:
Possible risk of irreversible effects. In rats, orally administered 8-hydroxyquinoline produced
deposition of iron in many tissues.
Section 4 - First Aid Measures
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by
medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH
(approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. This material in sufficient quantity and
reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Autoignition Temperature:
Not available
Flash Point:
Not available
NFPA Rating:
(estimated) Health: 2; Flammability: 1; Instability: 0
Explosion Limits:
Lower: n/a Upper: n/a
Section 6 - Accidental Release Measures
General Information:
Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty
conditions. Provide ventilation.
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Material Safety Data Sheet
8-Hydroxyquinoline
Section 7 - Handling and Storage
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with
adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on
clothing. Do not breathe dust.
Storage:
Store in a cool, dry place. Store in a tightly closed container. Store protected from light.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety
shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits:
Chemical Name: ACGIH NIOSH OSHA
8-Hydroxyquinoline none listed none listed none listed
OSHA Vacated PELs:
8-Hydroxyquinoline: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and
face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149.
Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are
exceeded or if irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Flakes
Color: Light yellow-slight beige
Odor: Odorless
pH: Not available
Vapor Pressure: 4.7 hPa @100篊
Vapor Density: Not available
Evaporation Rate: Not available
Viscosity: Not available
Boiling Point: 267篊 @ 752 mmHg
Freezing/Melting Point: 72 - 74篊
Decomposition Temperature: Not available
Solubility in water: Almost insoluble
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Material Safety Data Sheet
8-Hydroxyquinoline
Specific Gravity/Density: Not available
Molecular Formula: C9H7NO
Molecular Weight: 145.16
Section 10 - Stability and Reactivity
Chemical Stability:
Darkens and decomposes on exposure to light. Light sensitive.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen gas.
Hazardous Polymerization:
Has not been reported.
Section 11 - Toxicological Information
RTECS:
CAS# 148-24-3: VC4200000
LD50/LC50:
CAS# 148-24-3:
Draize test, rabbit, eye: 100 mg Mild;
Draize test, rabbit, skin: 500 mg/24H Mild;
Inhalation, rat: LC50 = >1210 mg/m3/6H;
Oral, mouse: LD50 = 20 gm/kg;
Oral, rat: LD50 = 1200 mg/kg
Carcinogenicity:
CAS# 148-24-3: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
There was no evidence of an increase in birth defects in 21 women treated with 8-hydroxyquinoline
during the first 16 weeks of pregnancy.
Reproductive:
No information found
Mutagenicity:
See actual entry in RTECS for complete information.
Neurotoxicity:
No information found
Section 12 - Ecological Information
No information found
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Material Safety Data Sheet
8-Hydroxyquinoline
Section 13 - Disposal Considerations
Dispose of in accordance with Federal, State, and local regulations.
Section 14 - Transport Information
US DOT
Shipping Name: Not regulated
Hazard Class:
UN Number:
Packing Group:
Section 15 - Regulatory Information
US Federal
TSCA:
CAS# 148-24-3 is listed on the TSCA inventory.
SARA Reportable Quantities (RQ):
None of the chemicals in this material have an RQ.
CERCLA/SARA Section 313:
No chemicals are reportable under Section 313.
OSHA - Highly Hazardous:
None of the chemicals in this product are considered highly hazardous by OSHA.
US State
State Right to Know:
CAS# 148-24-3 is not present on state lists from California, Pennsylvania, Minnesota,
Massachusetts, Florida, or New Jersey.
California Regulations:
None
European/International Regulations
Canadian DSL/NDSL:
CAS# 148-24-3 is listed on Canada's DSL List.
Canada Ingredient Disclosure List:
CAS# 148-24-3 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Other Information
MSDS Creation Date: November 13, 2007
Revision Date: June 19, 2008
Information in this MSDS is from available published sources and is believed to be accurate. No warranty, express or implied,
is made and LabChem Inc. assumes no liability resulting from the use of this MSDS. The user must determine suitability of this
information for his application.
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