SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 06/24/2003
Date Updated: 09/02/2002
Version 1.1
Section 1 - Product and Company Information
Product Name 2-MERCAPTOBENZOTHIAZOLE, 98%
Product Number M3302
Brand ALDRICH
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
2-MERCAPTOBENZOTHIAZOLE 149-30-4 Yes
Formula C7H5NS2
Synonyms Benzothiazole-2-thione,2(3H)-Benzothiazolethione,
2-Benzothiazolyl mercaptan,Captax,Kaptax (Czech),
MBT,Mercaptobenzothiazole,2-Mercaptobenzothiazole,
2-Merkaptobenzotiazol (Polish),
2-Merkaptobenzthiazol (Czech),NCI-C56519,
Pennac MBT powder,Rokon,Rotax,Sulfadene,USAF GY-3,
USAF XR-29,Vulkacit mercapto
RTECS Number: DL6475000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Toxic.
Toxic by inhalation, in contact with skin and if swallowed. May
cause sensitization by inhalation and skin contact. Limited
evidence of a carcinogenic effect.
Possible carcinogen.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
EYE EXPOSURE
Assure adequate flushing of the eyes by separating the eyelids
with fingers.
Section 5 - Fire Fighting Measures
FLASH POINT
469.4 癋 243 癈 Method: closed cup
EXPLOSION LIMITS
Lower: 15 %
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
EXPOSURE HAZARD(S)
Material: Toxic. Sensitizer.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid prolonged or repeated
exposure. Do not get in eyes, on skin, on clothing.
STORAGE
Suitable: Keep tightly closed. Store in a cool dry place.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
PERSONAL PROTECTIVE EQUIPMENT
Hand: Rubber gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
Section 9 - Physical/Chemical Properties
Appearance Color: Light yellow
Form: Powder
Property Value At Temperature or Pressure
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Molecular Weight 167.25 AMU
pH N/A
BP/BP Range N/A
MP/MP Range 178 癈
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient Log Kow: 2.41
Decomposition Temp. N/A
Flash Point 469.4 癋 243 癈 Method: closed cup
Explosion Limits Lower: 15 %
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin.
SENSITIZATION
Sensitization: May cause allergic respiratory and skin reactions
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Exposure can cause:
TOXICITY DATA
Oral
Rat
100 mg/kg
LD50
Inhalation
Rat
> 1,270 mg/m3
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LC50
Intraperitoneal
Rat
300 MG/KG
LD50
Oral
Mouse
1,158 mg/kg
LD50
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold.
Intraperitoneal
Mouse
100 MG/KG
LD50
Skin
Rabbit
> 7,940 mg/kg
LD50
Remarks: Behavioral:Food intake (animal). Behavioral:Change in
motor activity (specific assay).
Oral
Quail
> 2,150 mg/kg
LD50
CHRONIC EXPOSURE - CARCINOGEN
Species: Rat
Route of Application: Oral
Dose: 195 GM/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Leukemia Gastrointestinal:Tumors.
Species: Mouse
Route of Application: Oral
Dose: 35 GM/KG
Exposure Time: 78W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors. Blood:Tumors.
Species: Mouse
Route of Application: Subcutaneous
Dose: 215 MG/KG
Result: Tumorigenic:Carcinogenic by RTECS criteria. Blood:Tumors.
Species: Mouse
Route of Application: Oral
Dose: 195 GM/KG
Exposure Time: 2Y
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
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NTP CARCINOGEN LIST
Rating: Some evidence.
Species: Rat
Route: Gavage
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 400 MG/KG
Route of Application: Parenteral
Exposure Time: (4-11D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 4176 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities: Eye,
ear. Specific Developmental Abnormalities: Gastrointestinal
system.
CHRONIC EXPOSURE - MUTAGEN
Species: Hamster
Dose: 351 MG/L
Cell Type: ovary
Mutation test: Sister chromatid exchange
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 800 MG/KG
Route of Application: Parenteral
Exposure Time: (2D MALE/2D PRE)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Effects on Embryo or Fetus: Fetal death.
Section 12 - Ecological Information
No data available.
ACUTE ECOTOXICITY TESTS
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 1.71 - 2.960 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 0.6 - 0.96 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 0.025 mg/l
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Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Toxic solids, organic, n.o.s.
UN#: 2811
Class: 6.1
Packing Group: Packing Group III
Hazard Label: Keep away from food
PIH: Not PIH
IATA
Proper Shipping Name: Toxic solid, organic, n.o.s.
IATA UN Number: 2811
Hazard Class: 6.1
Packing Group: III
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xn N
Indication of Danger: Harmful. Dangerous for the environment.
R: 43 50/53
Risk Statements: May cause sensitization by skin contact. Very
toxic to aquatic organisms, may cause long-term adverse effects
in the aquatic environment.
S: 24 37 60 61
Safety Statements: Avoid contact with skin. Wear suitable
gloves. This material and its container must be disposed of as
hazardous waste. Avoid release to the environment. Refer to
special instructions/safety data sheets.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Toxic.
Risk Statements: Toxic by inhalation, in contact with skin and
if swallowed. May cause sensitization by inhalation and skin
contact. Limited evidence of a carcinogenic effect.
Safety Statements: Wear suitable protective clothing. Do not
breathe dust.
US Statements: Possible carcinogen.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
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For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide.
Sigma-Aldrich Inc., shall not be held liable for any damage
resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License
granted to make unlimited paper copies for internal use only.
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