Material Safety Data Sheet
Material Name: Clarifoam EF
* * * Section 1 - Chemical Product and Company Identification * * *
Manufacturer Information
Collegium Pharmaceutical
400 Highland Corporate Drive
Cumberland, RI 02864
Emergency Number: 1-888-713-8154
* * * Section 2 - Hazards Identification * * *
Emergency Overview
The product may cause allergic or sensitivity reaction for individuals sensitive to one or more of the components.
Potential Health Effects: Eyes
May cause irritation and stinging or burning.
Potential Health Effects: Skin
Allergic or sensitivity reactions are possible, causing irritation or redness.
Potential Health Effects: Ingestion
Not a likely route of entry. If swallowed may cause gastrointestinal discomfort.
Potential Health Effects: Inhalation
May cause respiratory irritation in some sensitive individuals.
HMIS Ratings: Health: 0 Fire: 1 HMIS Reactivity 0
Hazard Scale: 0 = Minimal 1 = Slight 2 = Moderate 3 = Serious 4 = Severe * = Chronic hazard
* * * Section 3 - Composition / Information on Ingredients * * *
CAS # Component
7732-18-5 Water
811-97-2 1,1,1,2-Tetrafluoroethane
6209-17-2 Acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium salt, monohydrate
57-55-6 1,2-Propylene glycol
7704-34-9 Sulfur
Trade Secret Emulsifying Wax
36653-82-4 Cetyl alcohol
9005-00-9 Polyoxyethylene monooctadecyl ether
99-76-3 Methyl p-hydroxybenzoate
94-13-3 Propyl-p-hydroxybenzoate
50-21-5 Lactic acid
* * * Section 4 - First Aid Measures * * *
First Aid: Eyes
Remove contact lenses. Immediately flush eyes with water for at least 15 minutes, while holding eyelids open.
Seek medical attention at once.
First Aid: Skin
Immediately take off all contaminated clothing. Physically remove as much of product as possible and thoroughly
wash the area with soap and water. If irritation persists, get medical attention.
First Aid: Ingestion
Do not induce vomiting unless directed to do so by medical personnel.
First Aid: Inhalation
None necessary.
* * * Section 5 - Fire Fighting Measures * * *
General Fire Hazards
See Section 9 for Flammability Properties.
None identified.
Hazardous Combustion Products
Burning may produce toxic gases.
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Page 1 of 5 Issue Date: 03/28/08 Revision: 2.0000 Print Date: 5/15/2008
Material Safety Data Sheet
Material Name: Clarifoam EF
Extinguishing Media
Use any media suitable for the surrounding fires.
Fire Fighting Equipment/Instructions
Fire fighters should wear full-face, self contained breathing apparatus and impervious protective clothing. Fire
fighters should avoid inhaling any combustion products.
NFPA Ratings: Health: 0 Fire: 1 Reactivity: 0
Hazard Scale: 0 = Minimal 1 = Slight 2 = Moderate 3 = Serious 4 = Severe
* * * Section 6 - Accidental Release Measures * * *
Containment Procedures
Contain the discharged material.
Clean-Up Procedures
Scoop material and place in a suitable container for disposal. Use soap and water to clean spill area.
Evacuation Procedures
None necessary.
Special Procedures
Wear appropriate personal protective equipment.
* * * Section 7 - Handling and Storage * * *
Handling Procedures
Avoid getting this material into contact with your eyes. Contents under pressure. Do not puncture or incinerate.
Keep out of reach of children. Wash thoroughly after handling.
Storage Procedures
Controlled room temperature (59-86癋). Do not expose to temperatures above 120癋 (49癈). Protect from
freezing.
* * * Section 8 - Exposure Controls / Personal Protection * * *
A: Component Exposure Limits
ACGIH, OSHA, and NIOSH have not developed exposure limits for any of this product's components.
Engineering Controls
Use general ventilation and use local exhaust, where possible, in confined or enclosed spaces.
PERSONAL PROTECTIVE EQUIPMENT
Personal Protective Equipment: Eyes/Face
Wear safety glasses; chemical goggles (if splashing is possible).
Personal Protective Equipment: Skin
Wear chemical resistant gloves and other protective clothing (lab coat, apron, etc.) when cleaning a large spill.
Personal Protective Equipment: Respiratory
Respiratory protection; not normally required for ambient air concentrations not exceeding the Occupational
Exposure Limit.
Personal Protective Equipment: General
None.
* * * Section 9 - Physical & Chemical Properties * * *
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Material Safety Data Sheet
Material Name: Clarifoam EF
Appearance: Odor:
Off-White to Pale Yellow Slight Sulfur Odor
Physical State: pH:
Foam 6-8
Vapor Pressure: Vapor Density:
ND ND
Boiling Point: Melting Point:
N/A N/A
Solubility (H2O): Specific Gravity:
ND ND
Evaporation Rate: VOC:
ND ND
Octanol/H2O Coeff.: Flash Point:
ND ND
Flash Point Method: Upper Flammability Limit
ND ND
(UFL):
Lower Flammability Limit Burning Rate:
ND ND
(LFL):
Auto Ignition: ND
* * * Section 10 - Chemical Stability & Reactivity Information * * *
Chemical Stability
Stable under normal conditions.
Chemical Stability: Conditions to Avoid
Excessive heat.
Incompatibility
None known
Hazardous Decomposition
Burning may produce toxic gases.
Possibility of Hazardous Reactions
None identified.
* * * Section 11 - Toxicological Information * * *
Acute Dose Effects
A: General Product Information
None identified.
B: Component Analysis - LD50/LC50
Water (7732-18-5)
Oral LD50 Rat: >90 mL/kg
1,1,1,2-Tetrafluoroethane (811-97-2)
Inhalation LC50 Rat: 1500 g/ m3/4H
1,2-Propylene glycol (57-55-6)
Oral LD50 Rat: 20000 mg/kg; Dermal LD50 Rabbit:20800 mg/kg
Sulfur (7704-34-9)
Inhalation LC50 Rat: >6.23 mg/L/4H; Oral LD50 Rat: >3000 mg/kg; Dermal LD50 Rabbit: >2000 mg/kg
Cetyl alcohol (36653-82-4)
Oral LD50 Rat: 5 g/kg; Dermal LD50 Rabbit: >2600 mg/kg
Polyoxyethylene monooctadecyl ether (9005-00-9)
Oral LD50 Rat: 2900 mg/kg
Methyl p-hydroxybenzoate (99-76-3)
Oral LD50 Rat: 2100 mg/kg
Propyl-p-hydroxybenzoate (94-13-3)
Oral LD50 Mouse: 6332 mg/kg
Lactic acid (50-21-5)
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Page 3 of 5 Issue Date: 03/28/08 Revision: 2.0000 Print Date: 5/15/2008
Material Safety Data Sheet
Material Name: Clarifoam EF
Oral LD50 Rat: 3543 mg/kg; Dermal LD50 Rabbit:>2 g/kg
Carcinogenicity
Component Carcinogenicity
None of this product's components are listed by ACGIH, IARC, OSHA, NIOSH, or NTP.
* * * Section 12 - Ecological Information * * *
Ecotoxicity
A: General Product Information
No data available for this product.
B: Component Analysis - Ecotoxicity - Aquatic Toxicity
1,2-Propylene glycol (57-55-6)
Test & Species Conditions
51600 mg/L [static]
96 Hr LC50 Oncorhynchus mykiss
51400 mg/L [static]
96 Hr LC50 Pimephales promelas
19000 mg/L
96 Hr EC50 Selenastrum
capricornutum
710 mg/L
30 min EC50 Photobacterium
phosphoreum
>10000 mg/L
48 Hr EC50 water flea
Sulfur (7704-34-9)
Test & Species Conditions
866 mg/L [static]
96 Hr LC50 Brachydanio rerio
* * * Section 13 - Disposal Considerations * * *
US EPA Waste Number & Descriptions
A: General Product Information
No information available for the product.
B: Component Waste Numbers
No EPA Waste Numbers are applicable for this product's components.
Disposal Instructions
All wastes must be handled in accordance with local, state and federal regulations.
See Section 7 for Handling Procedures. See Section 8 for Personal Protective Equipment recommendations.
* * * Section 14 - Transportation Information * * *
US DOT Information
Shipping Name: Not Regulated
* * * Section 15 - Regulatory Information * * *
US Federal Regulations
Component Analysis
None of this products components are listed under SARA Section 302 (40 CFR 355 Appendix A), SARA Section
313 (40 CFR 372.65), or CERCLA (40 CFR 302.4).
State Regulations
Component Analysis - State
The following components appear on one or more of the following state hazardous substances lists:
Component CAS CA MA MN NJ PA RI
1,1,1,2-Tetrafluoroethane 811-97-2 No No Yes No No No
1,2-Propylene glycol 57-55-6 No No Yes No Yes Yes
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Page 4 of 5 Issue Date: 03/28/08 Revision: 2.0000 Print Date: 5/15/2008
Material Safety Data Sheet
Material Name: Clarifoam EF
Sulfur 7704-34-9 Yes Yes No Yes Yes Yes
Additional Regulatory Information
Component Analysis - Inventory
Component CAS # TSCA
Water 7732-18-5 Yes
1,1,1,2-Tetrafluoroethane 811-97-2 Yes
Acetamide, N-[(4-aminophenyl)sulfonyl]-, 6209-17-2 No
monosodium salt, monohydrate
1,2-Propylene glycol 57-55-6 Yes
Sulfur 7704-34-9 Yes
Cetyl alcohol 36653-82-4 Yes
Polyoxyethylene monooctadecyl ether 9005-00-9 Yes
Methyl p-hydroxybenzoate 99-76-3 Yes
Propyl-p-hydroxybenzoate 94-13-3 Yes
Lactic acid 50-21-5 Yes
* * * Section 16 - Other Information * * *
Other Information
The information herein is presented in good faith and believed to be accurate as of the effective date given.
However, no warranty, expressed or implied, is given. It is the buyer's responsibility to ensure that its activities
comply with Federal, State or provincial, and local laws.
Key/Legend
EPA = Environmental Protection Agency; TSCA = Toxic Substance Control Act; ACGIH = American Conference
of Governmental Industrial Hygienists; IARC = International Agency for Research on Cancer; NIOSH = National
Institute for Occupational Safety and Health; NTP = National Toxicology Program; OSHA = Occupational Safety
and Health Administration., NJTSR = New Jersey Trade Secret Registry.
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