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Section 1 - Chemical Product and Company Identification |
MSDS Name: 10% Buffered formalin
Catalog Numbers:
SF99-20, SF99-4
Synonyms:
None.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 50-00-0 |
Formaldehyde |
3.9-4.0 | 200-001-8 |
| 67-56-1 |
Methyl alcohol |
2 | 200-659-6 |
| 127-09-3 |
Sodium acetate |
1.2-2.0 | 204-823-8 |
| 7732-18-5 |
Water |
Balance | 231-791-2 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: not available liquid. Flash Point: > 90 deg C.
Warning! Contains formaldehyde which can cause
cancer. Causes eye, skin, and respiratory tract irritation. May cause
allergic respiratory and skin reaction. May be harmful if swallowed
or absorbed through the skin. May cause central nervous system
depression. This substance has caused adverse reproductive and fetal
effects in animals.
Target Organs: Central nervous system, lungs,
respiratory system, skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic
reaction, which becomes evident upon re-exposure to this material.
Ingestion:
Cannot be made non-poisonous. May cause central nervous system
depression, kidney damage, and liver damage. Causes gastrointestinal
irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. May cause allergic respiratory
reaction.
Chronic:
Contains formaldehyde which can cause cancer in humans. There is
sufficient evidence that formaldehyde causes nasopharyngeal cancer in
humans, a rare cancer in developed countries. There is limited
evidence that formaldehyde causes cancer of the nasal cavity and
paranasal sinuses and strong but not sufficient evidence for
leukemia.
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or
alcohol-resistant foam. Cool containers with flooding quantities of
water until well after fire is out.
Flash Point: > 90 deg C (> 194.00 deg F)
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 2; Flammability: 1; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Clean up spills immediately,
observing precautions in the Protective Equipment section. Provide
ventilation.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Wash thoroughly after handling.
Remove contaminated clothing and wash before reuse. Do not get in
eyes, on skin, or on clothing. Keep container tightly closed. Do not
ingest or inhale. Use only with adequate ventilation.
Storage:
Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local exhaust ventilation to keep airborne concentrations below the
permissible exposure limits. See 29CFR 1910.1048 for regulatory
requirements pertaining to all occupational exposures to
formaldehyde, i.e., from formaldehyde gas, its solutions, and
materials that release formaldehyde.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Formaldehyde
|
0.3 ppm Ceiling
|
0.016 ppm TWA 20 ppm IDLH
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0.75 ppm TWA; 0.5 ppm Action Level; 0.75 ppm TWA; 2 ppm STEL (Irritant and potential cancer ha zard - see 29 CFR 1910.1048)
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| Methyl alcohol
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200 ppm TWA; 250 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute
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200 ppm TWA; 260 mg/m3 TWA 6000 ppm IDLH
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200 ppm TWA; 260 mg/m3 TWA
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| Sodium acetate
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none listed
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none listed
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none listed
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| Water
|
none listed
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none listed
|
none listed
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OSHA Vacated PELs:
Formaldehyde:
3 ppm TWA (unless specified in 1910.1048)
Methyl alcohol:
200 ppm TWA; 260 mg/m3 TWA
Sodium acetate:
No OSHA Vacated PELs are listed for this chemical.
Water:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: not available
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Soluble in water.
Specific Gravity/Density:Not available.
Molecular Formula:Mixture
Molecular Weight:Not applicable.
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Irritating and toxic gases.
Hazardous Polymerization: Has not been reported
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Section 11 - Toxicological Information
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RTECS#:
CAS# 50-00-0:
LP8925000
CAS# 67-56-1:
PC1400000
CAS# 127-09-3:
AJ4300010
CAS# 7732-18-5:
ZC0110000
LD50/LC50:
CAS# 50-00-0:
Draize test, rabbit,
eye: 750 ug/24H Severe;
Draize
test, rabbit, eye: 750 ug Severe;
Draize test, rabbit, eye: 10 mg
Severe;
Draize test, rabbit, eye:
37% Severe;
Draize test, rabbit,
skin: 2 mg/24H Severe;
Draize test,
rabbit, skin: 50 mg/24H Moderate;
Inhalation, mouse: LC50 = 454
mg/m3/4H;
Inhalation, mouse: LC50 =
505 mg/m3/2H;
Inhalation, rat: LC50
= 203 mg/m3;
Inhalation, rat: LC50
= 578 mg/m3/2H;
Inhalation, rat:
LC50 = 250 ppm/2H;
Oral, mouse:
LD50 = 42 mg/kg;
Oral, mouse: LD50
CAS# 67-56-1:
Draize test,
rabbit, eye: 40 mg Moderate;
Draize
test, rabbit, eye: 100 mg/24H Moderate;
Draize test, rabbit, skin: 20 mg/24H
Moderate;
Inhalation, rabbit: LC50
= 81000 mg/m3/14H;
Inhalation, rat:
LC50 = 64000 ppm/4H;
Oral, mouse:
LD50 = 7300 mg/kg;
Oral, rabbit:
LD50 = 14200 mg/kg;
Oral, rat:
LD50 = 5600 mg/kg;
Skin, rabbit:
LD50 = 15800 mg/kg;
.
CAS# 127-09-3:
Draize test,
rabbit, eye: 10 mg Mild;
Draize
test, rabbit, skin: 500 mg/24H Mild;
Inhalation, rat: LC50 = >30
gm/m3/1H;
Oral, mouse: LD50 = 6891
mg/kg;
Oral, rat: LD50 = 3530
mg/kg;
Skin, rabbit: LD50 = >10
gm/kg;
.
CAS# 7732-18-5:
Oral, rat:
LD50 = >90 mL/kg;
.
Carcinogenicity:
CAS# 50-00-0:
- ACGIH:
A2 - Suspected Human Carcinogen
- California:
carcinogen, initial date 1/1/88 (gas)
- NTP:
Suspect carcinogen
- IARC:
Group 1 carcinogen
CAS# 67-56-1:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 127-09-3:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 7732-18-5:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
In June 2004 an expert IARC group determined that there is
now sufficient evidence that formaldehyde causes
nasopharyngeal cancer in humans, a rare cancer in developed
countries.
Teratogenicity:
Formaldehyde effects on Newborn: behavioral, ihl-rat
TCLo=50 ug/m3/4H; biochemical/metabolic and reduced weight
gain, ihl-rat TCLo=12 ug/m3/24H. Embryo or Fetus:
cytological changes, ihl-rat TCLo=1 mg/m3/24H; stunted
fetus and death, ipr-mouse TDLo=240 mg/kg. Specific
Developmental Abnormalities: craniofacial and
musculoskeletal, ipr-mouse TDLo=240 mg/kg.
Reproductive Effects:
Formaldehyde effects on Fertility: male index, itt-rat
TDLo=400 mg/kg; post- implantation mortality, ims-mouse
TDLo=259 mg/kg. Paternal Effects: spermatogenesis, orl-rat
TDLo=200 mg/kg; testes/sperm duct/epididymis, ipr-rat
TDLo=80 mg/kg.
Mutagenicity:
Formaldehyde DNA Damage: human fibroblast 100 umol/L DNA
Inhibition: human cell types 210 umol/L. Unscheduled DNA
Synthesis: rat cell types 50 umol/L. Gene Mutation in
Mammalian Cells: human lymphocyte 130 umol/L.
Neurotoxicity:
No information available.
Other Studies:
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Section 12 - Ecological Information
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No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 50-00-0: waste
number U122.
CAS# 67-56-1: waste number U154
(Ignitable waste).
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
AVIATION REGULATED LIQUID, N.O.S. |
AVIATION REGULATED LIQUID, N.O.S. |
| Hazard Class: |
9 |
9 |
| UN Number: |
UN3334 |
UN3334 |
| Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 50-00-0 is listed on the TSCA inventory.
CAS# 67-56-1 is listed on the TSCA inventory.
CAS# 127-09-3 is listed on the TSCA inventory.
CAS# 7732-18-5 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 50-00-0: 100 lb final RQ; 45.4 kg final RQ
CAS# 67-56-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 50-00-0: 500 lb TPQ
SARA Codes
CAS # 50-00-0: immediate, delayed.
CAS # 67-56-1: immediate, fire.
Section 313
This material contains Formaldehyde
(CAS# 50-00-0, 3.9-4.0%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
This material contains Methyl
alcohol (CAS# 67-56-1, 2%),which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 50-00-0 is listed as a hazardous air pollutant (HAP).
CAS# 67-56-1 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 50-00-0 is listed as a Hazardous Substance under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
CAS# 50-00-0 is considered highly hazardous by OSHA.
STATE
CAS# 50-00-0 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 67-56-1 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 127-09-3 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
CAS# 7732-18-5 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Formaldehyde, a chemical known to the
state of California to cause cancer.
California No Significant Risk Level:
CAS# 50-00-0: 40 鎔/day NSRL
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 40 Limited evidence of a carcinogenic effect.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 50-00-0: 2
CAS# 67-56-1: 1
CAS# 127-09-3: 1
CAS# 7732-18-5: No information available.
Canada - DSL/NDSL
CAS# 50-00-0 is listed on Canada's DSL List.
CAS# 67-56-1 is listed on Canada's DSL List.
CAS# 127-09-3 is listed on Canada's DSL List.
CAS# 7732-18-5 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B3, D1B, D2A.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 50-00-0 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-56-1 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 7/12/1999
Revision #9 Date: 10/29/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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