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Section 1 - Chemical Product and Company Identification |
MSDS Name: p-Naphtholbenzein indicator solution
Catalog Numbers:
SN1-500
Synonyms:
None.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 108-88-3 |
Toluene |
54 | 203-625-9 |
| 67-63-0 |
2-Propanol |
45 | 200-661-7 |
| 145-50-6 |
1(4H)-Naphthalenone,4-(4-hydroxy-1-naphthalenyl)phenylmethyl ene- |
0.8 | 205-656-3 |
| 7732-18-5 |
Water |
0.2 | 231-791-2 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: clear red-brown liquid. Flash Point: 2.8 deg C.
Danger! Causes eye irritation and possible injury.
Poison! Vapor harmful. Harmful or fatal if swallowed.
Flammable liquid and vapor. May cause allergic skin
reaction. Aspiration hazard if swallowed. Can enter lungs and cause
damage. May cause respiratory and digestive tract irritation. May
cause skin irritation. May cause central nervous system depression.
May form explosive peroxides. May cause cardiac disturbances.
Target Organs: Kidneys, heart, central nervous
system, liver.
Potential Health Effects
Eye:
May result in corneal injury. Produces irritation, characterized
by a burning sensation, redness, tearing, inflammation, and possible
corneal injury. Vapors may cause eye irritation.
Skin:
May cause skin sensitization, an allergic reaction, which becomes
evident upon re-exposure to this material. Prolonged and/or repeated
contact may cause defatting of the skin and dermatitis. May cause
irritation with pain and stinging, especially if the skin is abraded.
Ingestion:
Aspiration hazard. May cause irritation of the digestive tract. May
cause gastrointestinal irritation with nausea, vomiting and
diarrhea. May cause central nervous system depression, characterized
by excitement, followed by headache, dizziness, drowsiness, and
nausea. Advanced stages may cause collapse, unconsciousness, coma
and possible death due to respiratory failure. Aspiration of
material into the lungs may cause chemical pneumonitis, which may be
fatal. May be harmful if swallowed.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Inhalation of vapor may cause respiratory tract irritation.
May cause liver and kidney damage. May cause heart disturbances,
possibly leading to cardiac arrest and death.
Chronic:
Chronic exposure to organic solvents has been associated with
various neurotoxic effects including permanent brain and nervous
system damage. May cause cardiac sensitization and severe heart
abnormalities. May cause liver and kidney damage. Repeated or
prolonged exposure may cause allergic reactions in sensitive
individuals.
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Flush skin with plenty of water for at least 15 minutes while
removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists. Remove contaminated clothing and
shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Never give anything by mouth to an
unconscious person. Possible aspiration hazard. Get medical aid
immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing
is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation. If breathing has ceased apply artificial respiration
using oxygen and a suitable mechanical device such as a bag and a
mask.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may
lead to cardiac arrhythmias. Do NOT use adrenergic agents such as
epinephrine or pseudoepinephrine.
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Section 5 - Fire Fighting Measures
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General Information:
Causes cardiac sensitization to endogenous catelcholamines which may
lead to cardiac arrhythmias. Do NOT use adrenergic agents such as
epinephrine or pseudoepinephrine. As in any fire, wear a
self-contained breathing apparatus in pressure-demand, MSHA/NIOSH
(approved or equivalent), and full protective gear. Water runoff can
cause environmental damage. Dike and collect water used to fight
fire. Vapors may form an explosive mixture with air. Use water spray
to keep fire-exposed containers cool. Water may be ineffective.
Material is lighter than water and a fire may be spread by the use
of water. Flammable liquid and vapor. May form explosive peroxides.
Containers may explode when heated.
Extinguishing Media:
Water may be ineffective. Use dry chemical, carbon dioxide, or
alcohol-resistant foam. Do NOT use straight streams of water. For
large fires, use dry chemical, carbon dioxide, alcohol-resistant
foam, or water spray. For small fires, use carbon dioxide, dry
chemical, dry sand, or alcohol-resistant foam.
Flash Point: 2.8 deg C ( 37.04 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 2; Flammability: 3; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Remove all sources of ignition. Absorb spill using an absorbent,
non-combustible material such as earth, sand, or vermiculite. Do not
use combustible materials such as sawdust. Provide ventilation. A
vapor suppressing foam may be used to reduce vapors. Water spray may
reduce vapor but may not prevent ignition in closed spaces.
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Section 7 - Handling and Storage
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Handling:
Remove contaminated clothing and wash before reuse. Use only in a
well-ventilated area. Ground and bond containers when transferring
material. Use spark-proof tools and explosion proof equipment. Avoid
contact with eyes, skin, and clothing. Empty containers retain
product residue, (liquid and/or vapor), and can be dangerous. Keep
container tightly closed. Keep away from heat, sparks and flame.
Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze,
solder, drill, grind, or expose empty containers to heat, sparks or
open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Store in a tightly closed container. Store in a cool, dry,
well-ventilated area away from incompatible substances.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Toluene
|
20 ppm TWA
|
100 ppm TWA; 375 mg/m3 TWA 500 ppm IDLH
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200 ppm TWA; 300 ppm Ceiling
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| 2-Propanol
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200 ppm TWA; 400 ppm STEL
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400 ppm TWA; 980 mg/m3 TWA 2000 ppm IDLH
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400 ppm TWA; 980 mg/m3 TWA
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| 1(4H)-Naphthalenone,4-(4-hydroxy-1-naphthalenyl)phenylmethyl ene-
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none listed
|
none listed
|
none listed
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| Water
|
none listed
|
none listed
|
none listed
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OSHA Vacated PELs:
Toluene:
100 ppm TWA; 375 mg/m3 TWA
2-Propanol:
400 ppm TWA; 980 mg/m3 TWA
1(4H)-Naphthalenone,4-(4-hydroxy-1-naphthalenyl)phenylmethyl ene-:
No OSHA Vacated PELs are listed for this chemical.
Water:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: clear red-brown
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: >1
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Insoluble in water.
Specific Gravity/Density:0.83
Molecular Formula:Mixture
Molecular Weight:Not available.
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions. This material may be sensitive to peroxide
formation.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid,
nitric acid, sulfuric acid), oxidizing agents (strong, e.g. bromine,
hydrogen peroxide, nitrogen dioxide, potassium nitrate), water
reactive substances (e.g. acetic anyhdride, alkyl aluminum chloride,
calcium carbide, ethyl dichlorosilane), acids (mineral,
non-oxidizing, e.g. hydrochloric acid, hydrofluoric acid, muriatic
acid, phosphoric acid), acids (organic, e.g. acetic acid, benzoic
acid, formic acid, methanoic acid, oxalic acid), azo, diazo, and
hydrazines (e.g. dimethyl hydrazine, hydrazine, methyl hydrazine),
isocyanates (e.g. methyl isocyanate), metals (alkali and alkaline,
e.g. cesium, potassium, sodium), nitrides (e.g. potassium nitride,
sodium nitride), peroxides and hydroperoxides (organic, e.g. acetyl
peroxide, benzoyl peroxide, butyl peroxide, methyl ethyl ketone
peroxide), epoxides (e.g. butyl glycidyl ether), reducing agents
(strong, e.g. aluminum carbide, chlorosilane, hydrogen phosphide,
lithium hydride), Isopropanol is susceptible to autoxidation and
therefore should be classified as peroxidizable..
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, acrid smoke and fumes.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 108-88-3:
XS5250000
CAS# 67-63-0:
NT8050000
CAS# 145-50-6
unlisted.
CAS# 7732-18-5:
ZC0110000
LD50/LC50:
CAS# 108-88-3:
Draize test,
rabbit, eye: 870 ug Mild;
Draize
test, rabbit, eye: 2 mg/24H Severe;
Draize test, rabbit, skin: 435 mg
Mild;
Draize test, rabbit, skin:
500 mg Moderate;
Draize test,
rabbit, skin: 20 mg/24H Moderate;
Inhalation, mouse: LC50 = 400
ppm/24H;
Inhalation, mouse: LC50 =
30000 mg/m3/2H;
Inhalation, mouse:
LC50 = 19900 mg/m3/7H;
Inhalation,
mouse: LC50 = 10000 mg/m3;
Inhalation, rat: LC50 = 49
gm/m3/4H;
Oral, rat: LD50 = 636
mg/kg;
Skin, rabbit: LD50 = 14100
CAS# 67-63-0:
Draize test,
rabbit, eye: 100 mg Severe;
Draize
test, rabbit, eye: 10 mg Moderate;
Draize test, rabbit, eye: 100 mg/24H
Moderate;
Draize test, rabbit,
skin: 500 mg Mild;
Inhalation,
mouse: LC50 = 53000 mg/m3;
Inhalation, rat: LC50 = 16000
ppm/8H;
Inhalation, rat: LC50 =
72600 mg/m3;
Oral, mouse: LD50 =
3600 mg/kg;
Oral, mouse: LD50 =
3600 mg/kg;
Oral, rabbit: LD50 =
6410 mg/kg;
Oral, rat: LD50 = 5045
mg/kg;
Oral, rat: LD50 = 5000
mg/kg;
Skin, rabbit: LD50 = 12800
CAS# 145-50-6:
.
CAS# 7732-18-5:
Oral, rat:
LD50 = >90 mL/kg;
.
Carcinogenicity:
CAS# 108-88-3:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 67-63-0:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 145-50-6:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 7732-18-5:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
Early epidemiological studies suggested an association
between the strong acid manufacture of iospropyl alcohol
and paranasal sinus cancer in workers. The risk of
laryngeal cancer may also be increased in these workers.
However, it has not been tested adequately in animals to
assess its carcinogenicity.
Teratogenicity:
In an epidemiologic study of toluene and pregnancy,
occupational exposures to toluene were said to be
associated with an increased incidence of renal, urinary,
gastrointestinal, and cardiac anomalies.Fetotoxicity
(reduced fetal weight), behavioural effects (effects on
learning and memory) and hearing loss (in males) were
observed in the offspring of rats exposed by inhalation to
toluene, in the absence of maternal toxicity.
Reproductive Effects:
Many reports of reproductive effects of toluene abuse or
heavy occupational exposure are confounded by mixed
solvent exposure or fetal alcohol syndrome. Women exposed
to toluene in lab work had a 4.7-fold increased risk of
spontaneous abortions.
Mutagenicity:
No information available.
Neurotoxicity:
No information available.
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
No information available.
Physical:
No information available.
Other:
None.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 108-88-3: waste
number U220.
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
FLAMMABLE LIQUIDS, N.O.S. |
No information available. |
| Hazard Class: |
3 |
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| UN Number: |
UN1993 |
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| Packing Group: |
II |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 108-88-3 is listed on the TSCA inventory.
CAS# 67-63-0 is listed on the TSCA inventory.
CAS# 145-50-6 is listed on the TSCA inventory.
CAS# 7732-18-5 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 108-88-3: Effective 10/4/82, Sunset 10/4/92
CAS# 67-63-0: Effective 12/15/86, Sunset 12/15/96
Chemical Test Rules
CAS# 67-63-0: 40 CFR 799.2325
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 108-88-3: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 108-88-3: immediate, fire.
CAS # 67-63-0: immediate, delayed, fire.
Section 313
This material contains Toluene
(CAS# 108-88-3, 54%),which is subject to the reporting requirements
of Section 313 of SARA Title III and 40 CFR Part 373.
This material contains 2-Propanol
(CAS# 67-63-0, 45%),which is subject to the reporting requirements of
Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 108-88-3 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 108-88-3 is listed as a Hazardous Substance under the CWA.
CAS# 108-88-3 is listed as a Priority Pollutant under the Clean Water
Act.
CAS# 108-88-3 is listed as a Toxic Pollutant under the Clean Water
Act.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 108-88-3 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 67-63-0 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 145-50-6 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
CAS# 7732-18-5 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
WARNING: This product contains Toluene, a chemical known to the state
of California to cause developmental reproductive toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN F
Risk Phrases:
R 11 Highly flammable.
R 36 Irritating to eyes.
R 20 Harmful by inhalation.
R 63 Possible risk of harm to the unborn child.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 24/25 Avoid contact with skin and eyes.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static discharges.
S 7 Keep container tightly closed.
WGK (Water Danger/Protection)
CAS# 108-88-3: 2
CAS# 67-63-0: 1
CAS# 145-50-6: No information available.
CAS# 7732-18-5: No information available.
Canada - DSL/NDSL
CAS# 108-88-3 is listed on Canada's DSL List.
CAS# 67-63-0 is listed on Canada's DSL List.
CAS# 145-50-6 is listed on Canada's DSL List.
CAS# 7732-18-5 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 108-88-3 is listed on the Canadian Ingredient Disclosure List.
CAS# 67-63-0 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 6/01/1999
Revision #6 Date: 1/31/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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