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Section 1 - Chemical Product and Company Identification |
MSDS Name: Methylmagnesium bromide, 3.2M solution in 2-Methyltetrahydrofuran
Catalog Numbers:
AC391120000, AC391121000
Synonyms:
None Known.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 96-47-9 |
Methyltetrahydrofuran |
63-67% | 202-507-4 |
| 75-16-1 |
Methyl magnesium bromide |
33-37% | 200-844-1 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: dark brown liquid. Flash Point: -11 deg C.
Danger! Reacts violently with water liberating
highly flammable gases. Extremely flammable liquid and vapor. Vapor
may cause flash fire. Causes burns by all exposure routes.
Water-reactive. Uninhibited material, or material from which the
inhibitor has been removed or reacted, may form explosive peroxides.
May be absorbed through intact skin. May be harmful if swallowed.
May cause central nervous system depression. May cause lung damage.
May cause liver and kidney damage.
Target Organs: Kidneys, central nervous system,
liver, lungs, respiratory system, gastrointestinal system, eyes,
skin.
Potential Health Effects
Eye:
Causes eye burns.
Damage may be permanent.
Skin:
Causes skin burns. May be absorbed through the skin.
Ingestion:
Causes gastrointestinal tract burns. May cause central nervous
system depression.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Causes chemical burns to the respiratory tract. Vapors may
cause dizziness or suffocation. Inhalation may cause coughing,
difficulty breathing and loss of consciousness.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause liver and kidney damage. May cause lung damage.
Narcotic in high concentrations.
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4
cupfuls of milk or water. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do NOT use
mouth-to-mouth resuscitation. If breathing has ceased apply
artificial respiration using oxygen and a suitable mechanical device
such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively. Persons with skin problems
or liver, kidney, lung, or blood diseases may be at increased risk
from exposure to this substance.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Exposure to heat may promote violent decomposition.
Water reactive. Material will react with water and may release a
flammable and/or toxic gas. May form explosive peroxides. Extremely
flammable liquid and vapor. Vapor may cause flash fire. Vapors are
heavier than air and may travel to a source of ignition and flash
back. Vapors can spread along the ground and collect in low or
confined areas.
Extinguishing Media:
Do NOT use water, carbon dioxide, or foam. Use sand, sodium
chloride, sodium carbonate, or dry chemical.
Flash Point: -11 deg C ( 12.20 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 3; Instability: 2; Special Hazard: -W-
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool. Isolate area and deny entry. Provide
ventilation. Do not expose spill to water. Do not let this chemical
enter the environment.
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Section 7 - Handling and Storage
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Handling:
Do not allow water to get into the container because of violent
reaction. Ground and bond containers when transferring material. Use
spark-proof tools and explosion proof equipment. Do not breathe dust,
mist, or vapor. Do not get in eyes, on skin, or on clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be
dangerous. Take precautionary measures against static discharges. Do
not ingest or inhale. Do not allow contact with water. Use only in a
chemical fume hood. Do not pressurize, cut, weld, braze, solder,
drill, grind, or expose empty containers to heat, sparks or open
flames. Keep away from heat, sparks and flame.
Storage:
Keep away from sources of ignition. Do not store in direct sunlight.
Store in a tightly closed container. Flammables-area. Water free
area. Regularly check inhibitor levels to maintain peroxide levels
below 1%. Store protected from moisture. Store under nitrogen. Store
at room temperature. Containers should be dated when opened and
tested periodically for the presence of peroxides. Should crystals
form in a peroxidizable liquid, peroxidation may have occurred and
the product should be considered extremely dangerous. In this
instance, the container should only be opened remotely by
professionals. All peroxidizable substances should be stored away
from heat and light and be protected from ignition sources.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local explosion-proof ventilation to keep airborne levels to
acceptable levels.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Methyltetrahydrofuran
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none listed
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none listed
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none listed
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| Methyl magnesium bromide
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none listed
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none listed
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none listed
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OSHA Vacated PELs:
Methyltetrahydrofuran:
No OSHA Vacated PELs are listed for this chemical.
Methyl magnesium bromide:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use. Follow the OSHA
respirator regulations found in 29 CFR 1910.134 or
European Standard EN 149. Use a NIOSH/MSHA or
European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or
other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: dark brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Not available.
Specific Gravity/Density:Not available.
Molecular Formula:CH3BrMg
Molecular Weight:119.24
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Section 10 - Stability and Reactivity
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Chemical Stability:
Decomposes when heated. Air sensitive. Reacts violently with water.
Moisture sensitive. Light sensitive. Under normal storage
conditions, peroxidizable compounds can form and accumulate
peroxides which may explode when subjected to heat or shock. This
material is most hazardous when peroxide levels are concentrated by
distillation or evaporation.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, exposure to
moist air or water, evaporating to near dryness, prolonged exposure
to air, excess light, confined spaces.
Incompatibilities with Other Materials:
Alcohols, oxidizing agents, water, acids, sodium aluminum hydride,
sodium tetrahydroaluminate, lithium tetrahydroaluminate, borane,
metal halides, strong oxidizing agents, strong acids, oxygen, caustic
alkalis, bromine.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, hydrogen bromide, benzene, methane.
Hazardous Polymerization: Has not been reported.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 96-47-9:
LU2800000
CAS# 75-16-1
unlisted.
LD50/LC50:
CAS# 96-47-9:
Draize test, rabbit,
eye: 500 mg/24H Mild;
Inhalation,
rat: LC50 = 6000 ppm/4H;
Skin,
rabbit: LD50 = 4500 mg/kg;
.
CAS# 75-16-1:
.
Carcinogenicity:
CAS# 96-47-9:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 75-16-1:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
Animal data show developmental effects only at exposure
levels producing other toxic effects in the adult animal.
Reproductive Effects:
Animal testing for reproductive effects shows no change in
reproductive performance.
Mutagenicity:
No information found
Neurotoxicity:
No information found
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay
(pH 7.5)Water flea Daphnia: EC50 =5930 mg/L; 24 Hr;
Tetrahydrofuran is not expected to adsorb to suspended matter in the
water based on its measured Koc values. This compound should
volatilize from water surfaces. An estimated BCF value of 1 suggests
that tetrahydrofuran will not bioconcentrate in aquatic organisms.
Environmental:
If released to the atmosphere, tetrahydrofuran will exist solely in
the vapor phase and is degraded in the atmosphere by reaction with
photochemically-produced hydroxyl radicals and nitrate radicals with
half-lives of about 1 and 3 days, respectively. Measured Koc values
of 23 and 18 indicate that tetrahydrofuran will have very high
mobility in soil.
Physical:
No information available.
Other:
No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER- REACTIVE, FLAMMABLE* |
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER- |
| Hazard Class: |
4.3 |
4.3 |
| UN Number: |
UN3399 |
UN3399 |
| Packing Group: |
I |
I |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 96-47-9 is listed on the TSCA inventory.
CAS# 75-16-1 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 96-47-9 can be found on the
following state right to know lists: Pennsylvania, Massachusetts.
CAS# 75-16-1 can be found on the
following state right to know lists: New Jersey.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
F C
Risk Phrases:
R 11 Highly flammable.
R 14/15 Reacts violently with water liberating extremely flammable
gases.
R 19 May form explosive peroxides.
R 34 Causes burns.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 33 Take precautionary measures against static discharges.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
otection.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 7/8 Keep container tightly closed and dry.
S 6A Keep under nitrogen.
S 43B In case of fire, use fire-fighting equipment on basis of sodiu
m chloride, sodium bicarbonate (never use water).
WGK (Water Danger/Protection)
CAS# 96-47-9: No information available.
CAS# 75-16-1: No information available.
Canada - DSL/NDSL
CAS# 96-47-9 is listed on Canada's NDSL List.
CAS# 75-16-1 is listed on Canada's NDSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, E, F.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 96-47-9 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 7/27/2006
Revision #1 Date: 2/08/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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