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Section 1 - Chemical Product and Company Identification |
MSDS Name: Propargyl bromide, 80 wt% solution in toluene, stabilized
Catalog Numbers:
AC131480000, AC131480500, AC131482500
Synonyms:
3-Bromopropyne.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 106-96-7 |
Propargyl bromide |
80 | 203-447-1 |
| 108-88-3 |
Toluene |
20 | 203-625-9 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: yellow liquid. Flash Point: 4 deg C.
Danger! Toxic if swallowed. Danger of serious
damage to health by prolonged exposure through inhalation. Causes
burns by all exposure routes. Flammable liquid and
vapor. Breathing vapors may cause drowsiness and
dizziness. Aspiration hazard if swallowed. Can enter lungs and cause
damage. May cause blood abnormalities. Possible risk of harm to the
unborn child. May cause central nervous system depression. May cause
liver and kidney damage.
Target Organs: Blood, kidneys, heart, central
nervous system, liver, respiratory system, gastrointestinal system,
eyes, skin.
Potential Health Effects
Eye:
Causes eye burns. Lachrymator (substance which increases the flow
of tears).
Skin:
Causes skin burns. May be harmful if absorbed through the skin.
Toluene is absorbed through the skin, but does not usually cause an
allergic skin reaction.
Ingestion:
Aspiration hazard. Causes gastrointestinal tract burns. Toxic if
swallowed. May cause lung damage.
Toluene is an aspiration hazard.
Inhalation:
Causes chemical burns to the respiratory tract. May be harmful if
inhaled. Inhalation of vapors may cause drowsiness and dizziness.
Eye and pulmonary irritation and liver and kidney injury were seen in
experimental animals with single or multiple exposures to vapor
concentrations of propargyl bromide as low as 10 ppm (Gosselin et al,
1984). All of the rats exposed to 1000 ppm of propargyl bromide for 1
hour, 200 ppm for 4 hours, and 120 ppm for 7 hours died. All rats
exposed to 1000 ppm for 0.2 hours, 200 ppm for 0.5 hours, and 120 ppm
for 2 hours survived.
Chronic:
May cause liver and kidney damage. Adverse reproductive effects have
been reported in animals. Laboratory experiments have resulted in
mutagenic effects. Chronic exposure may cause blood effects. Exposure
to high concentrations may cause central nervous system depression.
Possible risk of harm to the unborn child.
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical
personnel. Never give anything by mouth to an unconscious person. If
vomiting occurs naturally, have victim lean forward.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do not use
mouth-to-mouth resuscitation if victim ingested or inhaled the
substance; induce artificial respiration with the aid of a pocket
mask equipped with a one-way valve or other proper respiratory
medical device.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Will burn
if involved in a fire. Containers may explode in the heat of a fire.
Flammable liquid and vapor.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER!
Flash Point: 4 deg C ( 39.20 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 3; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Wear a self contained breathing
apparatus and appropriate personal protection. (See Exposure
Controls, Personal Protection section). Remove all sources of
ignition. Use a spark-proof tool. Do not let this chemical enter the
environment.
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Section 7 - Handling and Storage
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Handling:
Use spark-proof tools and explosion proof equipment. Keep away from
heat, sparks and flame. Use only in a chemical fume hood.
Storage:
Keep away from sources of ignition. Store in a tightly closed
container. Store in a dry area. Refrigerator/flammables.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower. Use only under a chemical fume hood.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Propargyl bromide
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none listed
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none listed
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none listed
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| Toluene
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20 ppm TWA
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100 ppm TWA; 375 mg/m3 TWA 500 ppm IDLH
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200 ppm TWA; 300 ppm Ceiling
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OSHA Vacated PELs:
Propargyl bromide:
No OSHA Vacated PELs are listed for this chemical.
Toluene:
100 ppm TWA; 375 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
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Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: yellow
Odor: characteristic odor
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: 4.10
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 88 - 90 deg C @ 760 mm Hg
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Immiscible.
Specific Gravity/Density:1.380
Molecular Formula:C3H3Br
Molecular Weight:118.96
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, hydrogen bromide.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 106-96-7:
UK4375000
CAS# 108-88-3:
XS5250000
LD50/LC50:
CAS# 106-96-7:
Oral, rat: LD50 =
53 mg/kg;
.
CAS# 108-88-3:
Draize test,
rabbit, eye: 870 ug Mild;
Draize
test, rabbit, eye: 2 mg/24H Severe;
Draize test, rabbit, skin: 435 mg
Mild;
Draize test, rabbit, skin:
500 mg Moderate;
Draize test,
rabbit, skin: 20 mg/24H Moderate;
Inhalation, mouse: LC50 = 400
ppm/24H;
Inhalation, mouse: LC50 =
30000 mg/m3/2H;
Inhalation, mouse:
LC50 = 19900 mg/m3/7H;
Inhalation,
mouse: LC50 = 10000 mg/m3;
Inhalation, rat: LC50 = 49
gm/m3/4H;
Oral, rat: LD50 = 636
mg/kg;
Skin, rabbit: LD50 = 14100
Carcinogenicity:
CAS# 106-96-7:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 108-88-3:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
Teratogenic effects have occurred in experimental animals.
Reproductive Effects:
Adverse reproductive effects have occurred in experimental
animals.
Mutagenicity:
Mutagenic effects have occurred in humans.
Neurotoxicity:
No information found
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
No information available.
Physical:
No information available.
Other:
Do not empty into drains.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 108-88-3: waste
number U220.
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
FLAMMABLE LIQUIDS, TOXIC, N.O.S. |
3-BROMOPROPYNE |
| Hazard Class: |
3 |
3 |
| UN Number: |
UN1992 |
UN2345 |
| Packing Group: |
II |
II |
| Additional Info: | | FLASHPOINT 18 C |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 106-96-7 is listed on the TSCA inventory.
CAS# 108-88-3 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 108-88-3: Effective 10/4/82, Sunset 10/4/92
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 108-88-3: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
CAS# 106-96-7: 10 lb TPQ
SARA Codes
CAS # 106-96-7: immediate, fire, reactive.
CAS # 108-88-3: immediate, fire.
Section 313
This material contains Toluene
(CAS# 108-88-3, 20%),which is subject to the reporting requirements
of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 108-88-3 is listed as a hazardous air pollutant (HAP).
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 108-88-3 is listed as a Hazardous Substance under the CWA.
CAS# 108-88-3 is listed as a Priority Pollutant under the Clean Water
Act.
CAS# 108-88-3 is listed as a Toxic Pollutant under the Clean Water
Act.
OSHA:
CAS# 106-96-7 is considered highly hazardous by OSHA.
STATE
CAS# 106-96-7 can be found on the
following state right to know lists: New Jersey, Pennsylvania,
Massachusetts.
CAS# 108-88-3 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
WARNING: This product contains Toluene, a chemical known to the state
of California to cause developmental reproductive toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T F
Risk Phrases:
R 11 Highly flammable.
R 25 Toxic if swallowed.
R 34 Causes burns.
R 48/20 Harmful : danger of serious damage to health by prolonged
exposure through inhalation.
R 63 Possible risk of harm to the unborn child.
R 65 Harmful: may cause lung damage if swallowed.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
otection.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 46 If swallowed, seek medical advice immediately and show this con
tainer or label.
S 28A After contact with skin, wash immediately with plenty of water
.
S 62 If swallowed, do not induce vomiting: seek medical advice immed
iately and show this container or label.
WGK (Water Danger/Protection)
CAS# 106-96-7: 3
CAS# 108-88-3: 2
Canada - DSL/NDSL
CAS# 108-88-3 is listed on Canada's DSL List.
CAS# 106-96-7 is listed on Canada's NDSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D1B, D2A, E.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 108-88-3 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 9/02/1997
Revision #11 Date: 1/31/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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