SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/MAY/2005
Date Updated: 19/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PRAZOSIN HYDROCHLORIDE
Product Number 81515
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PRAZOSIN HYDROCHLORIDE 19237-84-4 242-903-4 None
Formula C19H21N5O4 ?HCl
Molecular Weight 419.9 AMU
Synonyms 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-fur
anylcarbonyl)piperazine hydrochloride *
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-fur
oyl)piperazine monohydrochloride * CP-12299-1 *
Deprazolin * Furazosin hydrochloride *
2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimeth
oxyquinazoline hydrochloride * Hypovase *
Hypovasole * Minipress * Peripress * Piperazine,
1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-fur
oyl)-, monohydrochloride * Pratsiol * Prazosin
clorhidrato (Spanish) * Prazosin hydrochloride *
Sinetens
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Possible risk of impaired fertility.
Irritating to eyes, respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
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Appearance Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content <1%
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:1 mg/ml H2O clear,
colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: VA1350000
ACUTE TOXICITY
LD50
Oral
Rat
1950 mg/kg
Remarks: Gastrointestinal:Changes in structure or function of
salivary glands. Gastrointestinal:Nausea or vomiting. Kidney,
Ureter, Bladder:Other changes.
LD50
Intraperitoneal
Rat
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102 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Somnolence (general depressed
activity). Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Subcutaneous
Rat
3750 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Somnolence (general depressed
activity). Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Intravenous
Rat
73 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Dyspnea.
LD50
Oral
Mouse
5000 mg/kg
LD50
Intraperitoneal
Mouse
60 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia. Gastrointestinal:Hypermotility, diarrhea.
LD50
Subcutaneous
Mouse
3100 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Respiratory
depression.
LD50
Intravenous
Mouse
92 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Dyspnea.
LD50
Oral
Dog
> 700 mg/kg
Remarks: Gastrointestinal:Changes in structure or function of
salivary glands. Gastrointestinal:Nausea or vomiting. Kidney,
Ureter, Bladder:Other changes.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, dizziness, and headache. Other
symptoms of exposure may include sudden collapse, nasal
congestion, dry mouth, depression, diarrhea, drowsiness,
hypotension, nervousness, palpitations, difficulty in breathing,
urinary frequency, blurred vision, abnormality of sensation,
reddened eyes, tinnitus, skin rash, itching, tachycardia,
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impotence, vomiting, and fatigue. To the best of our knowledge,
the chemical, physical, and toxicological properties have not
been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Vascular system. Nerves.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 4150 MG/KG
Route of Application: Oral
Exposure Time: (8W MALE/2W PRE-9D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 300 MG/KG
Route of Application: Oral
Exposure Time: (9-14D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rabbit
Dose: 90 MG/KG
Route of Application: Oral
Exposure Time: (9-14D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rabbit
Dose: 450 MG/KG
Route of Application: Oral
Exposure Time: (9-14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 8700 MG/KG
Route of Application: Oral
Exposure Time: (14-22D PREG/20D POST)
Result: Effects on Newborn: Viability index (e.g., # alive at
day 4 per # born alive).
Species: Rat
Dose: 1450 MG/KG
Route of Application: Oral
Exposure Time: (14-22D PREG/20D POST)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
Species: Rat
Dose: 4 MG/KG
Route of Application: Subcutaneous
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Exposure Time: (22D PREG)
Result: Maternal Effects: Parturition.
Species: Rat
Dose: 12 MG/KG
Route of Application: Subcutaneous
Exposure Time: (4-5D PREG)
Result: Maternal Effects: Uterus, cervix, vagina. Maternal
Effects: Other effects.
Species: Rat
Dose: 1400 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Effects on Fertility: Male fertility index (e.g., # males
impregnating females per # males exposed to fertile nonpregnant
females). Effects on Fertility: Pre-implantation mortality
(e.g., reduction in number of implants per female; total number
of implants per corpora lutea).
Species: Rat
Dose: 30 MG/KG
Route of Application: Implant
Exposure Time: (3D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Effects on
Fertility: Male fertility index (e.g., # males impregnating
females per # males exposed to fertile nonpregnant females).
Species: Rat
Dose: 9125 MG/KG
Route of Application: Unreported
Exposure Time: (52W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Dog
Dose: 9125 MG/KG
Route of Application: Unreported
Exposure Time: (52W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
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IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 62 36/37/38
Harmful if swallowed. Possible risk of impaired fertility.
Irritating to eyes, respiratory system and skin.
S-PHRASES: 28 36
After contact with skin, wash immediately with plenty of water.
Wear suitable protective clothing.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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