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Section 1 - Chemical Product and Company Identification |
MSDS Name: Isopropylmagnesium chloride - Lithium chloride complex solution in
THF
Catalog Numbers:
AC386280000, AC386281000, AC386288000
Synonyms:
None Known.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 109-99-9 |
Tetrahydrofuran |
86% | 203-726-8 |
| 745038-86-2 |
Isopropylmagnesium chloride - Lithium chloride |
14% | unlisted |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: brown liquid.
Danger! Reacts violently with water liberating
highly flammable gases. Extremely flammable liquid and vapor. Vapor
may cause flash fire. Water-reactive. Causes burns by all exposure
routes. Uninhibited material, or material from which the inhibitor
has been removed or reacted, may form explosive peroxides. May be
absorbed through intact skin. May be harmful if swallowed. May cause
central nervous system depression. May cause lung damage. May cause
liver and kidney damage.
Target Organs: Kidneys, central nervous system,
liver, lungs, respiratory system, gastrointestinal system, eyes,
skin.
Potential Health Effects
Eye:
Causes eye burns.
Damage may be permanent.
Skin:
Causes skin burns.
THF is not a skin sensitizer in animals.
Ingestion:
Causes gastrointestinal tract burns. May be harmful if swallowed.
May cause central nervous system depression.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Causes chemical burns to the respiratory tract. May be
harmful if inhaled. Vapors may cause dizziness or suffocation.
Inhalation may cause coughing, difficulty breathing and loss of
consciousness.
Inhalation of tetrahydrofuran vapors may cause abnormal liver
function as detected by laboratory tests. (Dupont)
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause liver and kidney damage. May cause lung damage.
Narcotic in high concentrations.
Tetrahydrofuran data show carcinogenic activity in the liver and
kidneys of laboratory animals. The kidney tumors were by a mechanism
that has no relevance in humans. (Dupont)
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Section 4 - First Aid Measures
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Eyes:
In case of contact, immediately flush eyes with plenty of water for a
t least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, flush skin with plenty of water. Remove
contaminated clothing and shoes. Get medical aid if irritation
develops and persists. Wash clothing before reuse.
Ingestion:
Get medical aid immediately. Do NOT induce vomiting. If conscious
and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively. Persons with skin problems
or liver, kidney, lung, or blood diseases may be at increased risk
from exposure to this substance.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Water reactive. Material will react with water and
may release a flammable and/or toxic gas. Forms peroxides of unknown
stability. Extremely flammable liquid and vapor. Vapor may cause
flash fire. Vapors are heavier than air and may travel to a source
of ignition and flash back. Vapors can spread along the ground and
collect in low or confined areas.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER! Contact
professional fire-fighters immediately.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 3; Instability: 2; Special Hazard: -W-
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Sweep up, then place into a
suitable container for disposal. Remove all sources of ignition. Use
a spark-proof tool. Isolate area and deny entry. Provide ventilation.
Do not expose spill to water. A vapor suppressing foam may be used to
reduce vapors. Do not let this chemical enter the environment.
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Section 7 - Handling and Storage
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Handling:
Remove contaminated clothing and wash before reuse. Do not allow
water to get into the container because of violent reaction. Ground
and bond containers when transferring material. Use spark-proof tools
and explosion proof equipment. Do not breathe dust, vapor, mist, or
gas. Do not get in eyes, on skin, or on clothing. Empty containers
retain product residue, (liquid and/or vapor), and can be dangerous.
Take precautionary measures against static discharges. Do not ingest
or inhale. Use and store under nitrogen. Use only in a chemical fume
hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or
expose empty containers to heat, sparks or open flames. Keep away
from heat, sparks and flame.
Storage:
Keep away from sources of ignition. Store in a cool, dry place.
Store in a tightly closed container. Flammables-area. Regularly
check inhibitor levels to maintain peroxide levels below 1%. Store
protected from moisture. Containers should be dated when opened and
tested periodically for the presence of peroxides. Should crystals
form in a peroxidizable liquid, peroxidation may have occurred and
the product should be considered extremely dangerous. In this
instance, the container should only be opened remotely by
professionals. All peroxidizable substances should be stored away
from heat and light and be protected from ignition sources.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or
utilizing this material should be equipped with an eyewash facility
and a safety shower.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Tetrahydrofuran
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50 ppm TWA; 100 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute
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200 ppm TWA; 590 mg/m3 TWA 2000 ppm IDLH
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200 ppm TWA; 590 mg/m3 TWA
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| Isopropylmagnesium chloride - Lithium chloride
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none listed
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none listed
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none listed
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OSHA Vacated PELs:
Tetrahydrofuran:
200 ppm TWA; 590 mg/m3 TWA
Isopropylmagnesium chloride - Lithium chloride:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Reacts.
Specific Gravity/Density:1.050
Molecular Formula:C3H7Cl2LiMg
Molecular Weight:145.24
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Section 10 - Stability and Reactivity
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Chemical Stability:
Air sensitive. Reacts violently with water. Under normal storage
conditions, peroxidizable compounds can form and accumulate peroxides
which may explode when subjected to heat or shock. This material is
most hazardous when peroxide levels are concentrated by distillation
or evaporation. THF should never be distilled to dryness. Prolonged
exposure to air, even from extended storage time, can deplete BHT
inhibitor and rapidly accelerate THF-peroxide formation.
Conditions to Avoid:
Incompatible materials, light, ignition sources, exposure to air,
excess heat, exposure to moist air or water, evaporating to near
dryness, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, oxygen, bromine, metal
halides, lithium tetrahydroaluminate, borane, sodium aluminum
hydride, sodium tetrahydroaluminate, caustic alkalis.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, oxides of magnesium, lithium oxide.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 109-99-9:
LU5950000
CAS# 745038-86-2
unlisted.
LD50/LC50:
CAS# 109-99-9:
Inhalation, rat:
LC50 = 21000 ppm/3H;
Oral, rat:
LD50 = 1650 mg/kg;
.
CAS# 745038-86-2:
.
Carcinogenicity:
CAS# 109-99-9:
- ACGIH:
A3 - Confirmed animal carcinogen with unknown relevance to humans
- California:
Not listed.
- NTP:
Not listed.
- IARC:
Not listed.
CAS# 745038-86-2:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information found
Teratogenicity:
Animal data show developmental effects only at exposure
levels producing other toxic effects in the adult animal.
Reproductive Effects:
Animal testing for reproductive effects shows no change in
reproductive performance.
Mutagenicity:
THF has not produced genetic damage in mammalian cell
cultures or in animals. It has not been tested for its
ability to cause permanent genetic damage in reproductive
cells of mammals (not tested for heritable genetic
damage).
Neurotoxicity:
No information found
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay
(pH 7.5)Water flea Daphnia: EC50 =5930 mg/L; 24 Hr;
Tetrahydrofuran is not expected to adsorb to suspended matter in the
water based on its measured Koc values. This compound should
volatilize from water surfaces. An estimated BCF value of 1 suggests
that tetrahydrofuran will not bioconcentrate in aquatic organisms.
Environmental:
If released to the atmosphere, tetrahydrofuran will exist solely in
the vapor phase and is degraded in the atmosphere by reaction with
photochemically-produced hydroxyl radicals and nitrate radicals with
half-lives of about 1 and 3 days, respectively. Measured Koc values
of 23 and 18 indicate that tetrahydrofuran will have very high
mobility in soil.
Physical:
No information available.
Other:
No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 109-99-9: waste
number U213 (Ignitable waste).
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER- REACTIVE, FLAMMABLE* |
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER- |
| Hazard Class: |
4.3 |
4.3 |
| UN Number: |
UN3399 |
UN3399 |
| Packing Group: |
I |
I |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 109-99-9 is listed on the TSCA inventory.
CAS# 745038-86-2 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
CAS# 109-99-9: 40 CFR 799.5000; 40 CFR 799.5115
Section 12b
CAS# 109-99-9: Section 4
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 109-99-9: immediate, fire, reactive.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 109-99-9 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 745038-86-2 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
F C
Risk Phrases:
R 11 Highly flammable.
R 14/15 Reacts violently with water liberating extremely flammable
gases.
R 19 May form explosive peroxides.
R 34 Causes burns.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 33 Take precautionary measures against static discharges.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr
otection.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 7/8 Keep container tightly closed and dry.
S 43B In case of fire, use fire-fighting equipment on basis of sodiu
m chloride, sodium bicarbonate (never use water).
WGK (Water Danger/Protection)
CAS# 109-99-9: 1
CAS# 745038-86-2: No information available.
Canada - DSL/NDSL
CAS# 109-99-9 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of E, F.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 109-99-9 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 1/19/2006
Revision #1 Date: 5/02/2006
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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