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Section 1 - Chemical Product and Company Identification |
MSDS Name: Lithium (trimethylsilyl)acetylide, 0.5M solution in THF
Catalog Numbers:
AC380650000, AC380651000, AC380658000
Synonyms:
(Trimethylsilyl)ethynyl lithium
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 109-99-9 |
Tetrahydrofuran |
95% | 203-726-8 |
| 54655-07-1 |
Lithium (trimethylsilyl)acetylide |
5% | unlisted |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: colorless liquid.
Air sensitive. Moisture sensitive.
Target Organs: Kidneys, central nervous system,
liver, respiratory system, eyes, skin.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye
burns. Vapors may cause eye irritation. Contact may cause
ulceration of the conjunctiva and cornea.
Skin:
Causes skin irritation. Prolonged and/or repeated contact may cause
defatting of the skin and dermatitis. May be harmful if absorbed
through the skin. No sensitizing effects known.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
May cause gastrointestinal irritation with nausea, vomiting and
diarrhea.
Inhalation:
Inhalation of high concentrations may cause central nervous system
effects characterized by nausea, headache, dizziness, unconsciousness
and coma. Causes respiratory tract irritation. May be harmful if
inhaled.
Chronic:
Prolonged or repeated eye contact may cause conjunctivitis.
Prolonged or repeated skin contact may cause defatting and
dermatitis. May cause liver and kidney damage.
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Section 4 - First Aid Measures
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Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Discard
contaminated clothing in a manner which limits further exposure.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid. Get medical aid immediately. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors can travel to a source of ignition and flash
back. Will burn if involved in a fire. Water reactive. Material will
react with water and may release a flammable and/or toxic gas. Forms
peroxides of unknown stability. Flammable liquid and vapor.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Water may be
ineffective. Use water spray, dry chemical, carbon dioxide, or
chemical foam.
Flash Point: Not available.
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
2 - health, 3 - flammability, 1 - instability
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool.
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Section 7 - Handling and Storage
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Handling:
Use only in a well-ventilated area. Avoid breathing dust, mist, or
vapor. Avoid contact with eyes, skin, and clothing. Avoid contact
with skin and eyes. Keep container tightly closed. Keep away from
heat, sparks and flame. Avoid ingestion and inhalation. Prevent build
up of vapors to explosive concentration.
Storage:
Keep away from heat, sparks, and flame. Store in a cool place in the
original container and protect from sunlight. Store in a cool, dry
place. Store in a tightly closed container. Keep from contact with
oxidizing materials. Flammables-area. Regularly check inhibitor
levels to maintain peroxide levels below 1%. Store under an inert
atmosphere.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local explosion-proof ventilation to keep airborne levels to
acceptable levels.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Tetrahydrofuran
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50 ppm TWA; 100 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute
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200 ppm TWA; 590 mg/m3 TWA 2000 ppm IDLH (10% LEL)
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200 ppm TWA; 590 mg/m3 TWA
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| Lithium (trimethylsilyl)acetylide
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none listed
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none listed
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none listed
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OSHA Vacated PELs:
Tetrahydrofuran:
200 ppm TWA; 590 mg/m3 TWA
Lithium (trimethylsilyl)acetylide:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Not available.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin. Wear appropriate protective
clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
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Section 9 - Physical and Chemical Properties
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Physical State: Liquid
Appearance: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: reacts
Specific Gravity/Density:0.880
Molecular Formula:C5H9LiSi
Molecular Weight:104.15
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures. Prolonged exposure
to air and sunlight may form unstable peroxides.
Conditions to Avoid:
Prolonged exposure to air and sunlight may form unstable peroxides.,
light, exposure to air, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, sodium hydroxide, caustics (e.g. ammonia,
ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium
hydroxide), oxidizing agents (strong, e.g. bromine, hydrogen
peroxide, nitrogen dioxide, potassium nitrate), potassium hydroxide,
bromine, metal halides.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, silicon dioxide, oxides of lithium.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 109-99-9:
LU5950000
CAS# 54655-07-1
unlisted.
LD50/LC50:
CAS# 109-99-9:
Inhalation, rat:
LC50 = 21000 ppm/3H;
Oral, rat:
LD50 = 1650 mg/kg;
.
CAS# 54655-07-1:
.
Carcinogenicity:
CAS# 109-99-9:
- ACGIH:
A3 - Confirmed animal carcinogen with unknown relevance to humans
- California:
Not listed.
- NTP:
Not listed.
- IARC:
Not listed.
CAS# 54655-07-1:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No data available.
Teratogenicity:
No data available.
Reproductive Effects:
No data available.
Mutagenicity:
No data available.
Neurotoxicity:
No data available.
Other Studies:
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Section 12 - Ecological Information
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No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 109-99-9: waste
number U213 (Ignitable waste).
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Section 14 - Transport Information
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| |
US DOT |
Canada TDG |
| Shipping Name: |
TETRAHYDROFURAN, SOLUTION |
No information available. |
| Hazard Class: |
3 |
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| UN Number: |
UN2056 |
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| Packing Group: |
II |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 109-99-9 is listed on the TSCA inventory.
CAS# 54655-07-1 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
CAS# 109-99-9: 40 CFR 799.5000; 40 CFR 799.5115
Section 12b
CAS# 109-99-9: Section 4, 1 % de minimus concentration
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 109-99-9: immediate, fire, reactive.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 109-99-9 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
CAS# 54655-07-1 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XI F
Risk Phrases:
R 11 Highly flammable.
R 14 Reacts violently with water.
R 19 May form explosive peroxides.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 16 Keep away from sources of ignition - No smoking.
S 18 Handle and open container with care.
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static discharges.
S 37/39 Wear suitable gloves and eye/face protection.
WGK (Water Danger/Protection)
CAS# 109-99-9: 1
CAS# 54655-07-1: No information available.
Canada - DSL/NDSL
CAS# 109-99-9 is listed on Canada's DSL List.
Canada - WHMIS
not available.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 109-99-9 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 8/04/2005
Revision #1 Date: 3/26/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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