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Section 1 - Chemical Product and Company Identification |
MSDS Name: 4-Nitroaniline
Catalog Numbers:
AC128370000, AC128370250, AC128371000, AC128375000, AC180690000,
AC180690050, 18069-1000, 18069-5000
Synonyms:
p-Nitroaniline; p-Nitrophenylamine; 1-Amino-4-nitrobenzene;
4-Nitrobenzenamine.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 100-01-6 |
4-Nitroaniline |
99+ | 202-810-1 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: brown solid.
Danger! Toxic if swallowed, inhaled or absorbed
through the skin. Harmful to aquatic organisms; may cause long-term
adverse effects in the aquatic environment. May cause eye, skin, and
respiratory tract irritation. Danger of cumulative effects. May
cause methemoglobinemia.
Target Organs: Blood, kidneys, central nervous
system, liver, spleen.
Potential Health Effects
Eye:
May cause eye irritation. May result in corneal injury.
Skin:
May cause skin irritation. Toxic in contact with skin.
Ingestion:
May cause irritation of the digestive tract. Poison by ingestion.
May cause methemoglobinemia, cyanosis (bluish discoloration of skin
due to deficient oxygenation of the blood), convulsions, and death.
May cause nausea and vomiting.
Inhalation:
May cause respiratory tract irritation. May cause methemoglobinemia,
cyanosis (bluish discoloration of skin due to deficient oxygenation
of the blood), convulsions, tachycardia, dyspnea (labored breathing),
and death. Toxic if inhaled. May cause nausea, dizziness, and
headache.
Chronic:
May cause liver and kidney damage. May cause methemoglobinemia,
which is characterized by chocolate-brown colored blood, headache,
weakness, dizziness, breath shortness, cyanosis (bluish skin due to
deficient oxygenation of blood), rapid heart rate, unconsciousness
and possible death. Repeated exposure may cause damage to the
spleen. Adverse reproductive effects have been reported in animals.
Laboratory experiments have resulted in mutagenic effects. Chronic
exposure may cause blood effects. There is a danger of cumulative
effects. Exposure to high concentrations may cause central nervous
system depression. Animal studies have reported the development of
tumors.
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Section 4 - First Aid Measures
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Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid imme
diately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of
water for at least 15 minutes while removing contaminated clothing
and shoes.
Ingestion:
POISON material. If swallowed, get medical aid immediately. Only
induce vomiting if directed to do so by medical personnel. Never give
anything by mouth to an unconscious person.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh
air immediately. If breathing is difficult, give oxygen. Do not use
mouth-to-mouth resuscitation if victim ingested or inhaled the
substance; induce artificial respiration with the aid of a pocket
mask equipped with a one-way valve or other proper respiratory
medical device.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: 199 deg C ( 390.20 deg F)
Autoignition Temperature: 510 deg C ( 950.00 deg F)
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 3; Flammability: 1; Instability: 1
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Wear a self contained breathing apparatus and appropriate
personal protection. (See Exposure Controls, Personal Protection
section). Avoid generating dusty conditions. Provide ventilation. Do
not let this chemical enter the environment.
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Section 7 - Handling and Storage
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Handling:
Minimize dust generation and accumulation. Do not get in eyes, on
skin, or on clothing. Do not ingest or inhale. Use only in a
chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use only under a
chemical fume hood.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| 4-Nitroaniline
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3 mg/m3 TWA; Skin - potential significant contribution to overall exposure by the cutaneous r oute
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3 mg/m3 TWA 300 mg/m3 IDLH
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1 ppm TWA; 6 mg/m3 TWA
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OSHA Vacated PELs:
4-Nitroaniline:
3 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
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Section 9 - Physical and Chemical Properties
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Physical State: Solid
Appearance: yellow - ochre - brown
Odor: ammonia-like - pungent odor - faint odor
pH: CA. 7 (sat.sol.)
Vapor Pressure: 1 mm Hg @142 deg C
Vapor Density: 4.77 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 332 deg C @ 760 mmHg
Freezing/Melting Point:146 - 151 deg C
Decomposition Temperature:> 260 deg C
Solubility: 0.8 g/L (20癈)
Specific Gravity/Density:Not available.
Molecular Formula:C6H6N2O2
Molecular Weight:138.13
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Section 10 - Stability and Reactivity
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Chemical Stability:
Moisture sensitive. Heat sensitive
Conditions to Avoid:
Incompatible materials, dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Strong reducing agents, strong oxidizing agents, strong acids, bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 100-01-6:
BY7000000
LD50/LC50:
CAS# 100-01-6:
Dermal, guinea pig:
LD50 = >500 mg/kg;
Oral, mouse:
LD50 = 810 mg/kg;
Oral, rat: LD50 =
750 mg/kg;
.
Carcinogenicity:
CAS# 100-01-6:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
Tumorigenic effects have been reported in experimental
animals.
Teratogenicity:
Teratogenic effects have occurred in experimental animals.
Reproductive Effects:
Adverse reproductive effects have occurred in experimental
animals.
Mutagenicity:
Mutagenic effects have occurred in experimental animals.
Neurotoxicity:
No information available.
Other Studies:
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Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
No information available.
Physical:
No information available.
Other:
Do not empty into drains.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: CAS# 100-01-6: waste number
P077.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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US DOT |
Canada TDG |
| Shipping Name: |
NITROANILINES |
NITROANILINES |
| Hazard Class: |
6.1 |
6.1 |
| UN Number: |
UN1661 |
UN1661 |
| Packing Group: |
II |
II |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 100-01-6 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
CAS# 100-01-6: 40 CFR 799.5115
Section 12b
CAS# 100-01-6: Section 4, 1 % de minimus concentration
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
CAS# 100-01-6: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 100-01-6: immediate, delayed, reactive.
Section 313
This material contains
4-Nitroaniline (CAS# 100-01-6, 99+%),which is subject to the
reporting requirements of Section 313 of SARA Title III and 40 CFR
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
CAS# 100-01-6 is considered highly hazardous by OSHA.
STATE
CAS# 100-01-6 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin and if
swallowed.
R 33 Danger of cumulative effects.
R 52/53 Harmful to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
Safety Phrases:
S 36/37 Wear suitable protective clothing and gloves.
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
S 28A After contact with skin, wash immediately with plenty of water
.
WGK (Water Danger/Protection)
CAS# 100-01-6: 2
Canada - DSL/NDSL
CAS# 100-01-6 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D1B.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 100-01-6 is listed on the Canadian Ingredient Disclosure List.
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Section 16 - Additional Information
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MSDS Creation Date: 11/05/1998
Revision #5 Date: 3/24/2008
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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