MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
VENTANA MEDICAL SYSTEMS INC. EMERGENCY TELEPHONE NUMBER:
1910 E. Innovation Park Drive (800) 424-9300 (USA/Canada)
Tucson, Arizona 85755 (CHEMTREC)
(520) 887-2155 +1 (703) 527-3887 (International)
MSDS NUMBER: 00231463
SUBSTANCE: AEC
PRODUCT NUMBER(S): 253-2006
PRODUCT USE: clinical/research
CREATION DATE: Dec 19 2005
REVISION DATE: Mar 15 2007
2. HAZARDS IDENTIFICATION
NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=2 REACTIVITY=0
EC CLASSIFICATION:
Xi Irritant
RISK PHRASES:
R 36/37/38 Irritating to eyes, respiratory system and skin.
EMERGENCY OVERVIEW:
COLOR: golden to reddish-brown
PHYSICAL FORM: liquid
ODOR: almond odor
MAJOR HEALTH HAZARDS: respiratory tract irritation, skin irritation, eye irritation, allergic reactions
PHYSICAL HAZARDS: Flash back hazard. Combustible liquid and vapor.
POTENTIAL HEALTH EFFECTS:
INHALATION:
SHORT TERM EXPOSURE: irritation, cough, allergic reactions, wheezing, difficulty breathing
LONG TERM EXPOSURE: allergic reactions
SKIN CONTACT:
SHORT TERM EXPOSURE: irritation, allergic reactions, absorption may occur, garlic breath, garlic odor
LONG TERM EXPOSURE: irritation, allergic reactions
EYE CONTACT:
SHORT TERM EXPOSURE: irritation, blurred vision
LONG TERM EXPOSURE: irritation
INGESTION:
SHORT TERM EXPOSURE: gastrointestinal irritation, allergic reactions, nausea, vomiting
LONG TERM EXPOSURE: allergic reactions
3. COMPOSITION, INFORMATION ON INGREDIENTS
COMPONENT: DIMETHYL SULFOXIDE
CAS NUMBER: 67-68-5
EC NUMBER (EINECS): 200-664-3
PERCENTAGE: 30-60
EC CLASSIFICATION: Xi
RISK PHRASES: 36-37-38
COMPONENT: NON-HAZARDOUS
CAS NUMBER: Not assigned.
EC NUMBER: Not assigned.
PERCENTAGE: 30-60
EC CLASSIFICATION: No classification assigned.
COMPONENT: SODIUM METABISULFITE
CAS NUMBER: 7681-57-4
EC NUMBER (EINECS): 231-673-0
PERCENTAGE: 1-5
EC CLASSIFICATION: Xn; Xi
RISK PHRASES: 22-31-41
COMPONENT: 3-AMINO-9-ETHYLCARBAZOLE
CAS NUMBER: 132-32-1
EC NUMBER (EINECS): 205-057-7
PERCENTAGE: <1
EC CLASSIFICATION: No classification assigned.
COMPONENT: ACETIC ACID
CAS NUMBER: 64-19-7
EC NUMBER (EINECS): 200-580-7
PERCENTAGE: <1
EC CLASSIFICATION: Flammable; C
RISK PHRASES: 10-35
4. FIRST AID MEASURES
INHALATION: If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not
breathing. Get immediate medical attention.
SKIN CONTACT: Wash contaminated areas with soap and water. Thoroughly clean and dry contaminated
clothing before reuse. Get medical attention, if needed.
EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical
attention.
INGESTION: If a large amount is swallowed, get medical attention.
5. FIRE FIGHTING MEASURES
FIRE AND EXPLOSION HAZARDS: Moderate fire hazard. Vapor/air mixtures are explosive above flash
point. The vapor is heavier than air. Vapors or gases may ignite at distant ignition sources and flash back.
EXTINGUISHING MEDIA: carbon dioxide, regular dry chemical, regular foam, water
FIRE FIGHTING: Move container from fire area if it can be done without risk. Cool containers with water
spray until well after the fire is out. Flood with fine water spray. Do not scatter spilled material with high-
pressure water streams. Avoid inhalation of material or combustion by-products.
SENSITIVITY TO MECHANICAL IMPACT: Not sensitive
SENSITIVITY TO STATIC DISCHARGE: Yes
FLASH POINT: 192 F (88.9 C) (CC, DIMETHYL SULFOXIDE)
FLAMMABILITY CLASS (OSHA): IIIA
HAZARDOUS COMBUSTION PRODUCTS:
Thermal decomposition products or combustion: oxides of carbon
6. ACCIDENTAL RELEASE MEASURES
WATER RELEASE:
Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Keep out of
water supplies and sewers.
OCCUPATIONAL RELEASE:
Avoid heat, flames, sparks and other sources of ignition. Stop leak if possible without personal risk. Reduce
vapors with water spray. Small spills: Absorb with sand or other non-combustible material. Collect spilled
material in appropriate container for disposal.
7. HANDLING AND STORAGE
STORAGE: Store and handle in accordance with all current regulations and standards. Store between 2 C
and 8 C. Subject to storage regulations: U.S. OSHA 29 CFR 1910.106. Grounding and bonding required. See
original container for storage recommendations. Keep separated from incompatible substances.
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
EXPOSURE LIMITS:
DIMETHYL SULFOXIDE:
DFG MAK (cutaneous absorption danger)
250 ppm AIHA WEEL recommended TWA
SODIUM METABISULFITE:
5 mg/m3 OSHA TWA (vacated by 58 FR 35338, June 30, 1993)
5 mg/m3 ACGIH TWA
5 mg/m3 NIOSH recommended TWA 10 hour(s)
5 mg/m3 UK WEL TWA
VENTILATION: Provide adequate ventilation. Ensure compliance with applicable exposure limits.
EYE PROTECTION: Safety glasses or goggles are recommended when there is a potential for eye contact.
Provide an emergency eye wash fountain and quick drench shower in the immediate work area.
CLOTHING: Lab coat or apron.
GLOVES: Wear appropriate chemical resistant gloves.
PROTECTIVE MATERIAL TYPES: latex, nitrile
RESPIRATOR: No respirator is required under normal conditions of use.
9. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: liquid
COLOR: golden to reddish-brown
ODOR: almond odor
BOILING POINT: 372 F (189 C) (DIMETHYL SULFOXIDE)
FREEZING POINT: Not available
VAPOR PRESSURE: Not available
VAPOR DENSITY (air=1): 2.7 (DIMETHYL SULFOXIDE)
SPECIFIC GRAVITY: Not available
WATER SOLUBILITY: miscible
PH: weakly acidic
VOLATILITY: 40-60%
ODOR THRESHOLD: Not available
EVAPORATION RATE: Not available
COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available
10. STABILITY AND REACTIVITY
REACTIVITY: Stable at normal temperatures and pressure.
CONDITIONS TO AVOID: Avoid heat, flames, sparks and other sources of ignition. Containers may
rupture or explode if exposed to heat. Keep out of water supplies and sewers.
INCOMPATIBILITIES: oxidizing materials, acids, reducing agents
HAZARDOUS DECOMPOSITION:
Thermal decomposition products or combustion: oxides of carbon
POLYMERIZATION: Will not polymerize.
11. TOXICOLOGICAL INFORMATION
DIMETHYL SULFOXIDE:
IRRITATION DATA: 10 mg/24 hour(s) open skin-rabbit mild; 500 mg/24 hour(s) skin-rabbit mild; 100
mg eyes-rabbit; 500 mg/24 hour(s) eyes-rabbit mild
TOXICITY DATA: 50 gm/kg skin-mouse LD50; 14500 mg/kg oral-rat LD50
LOCAL EFFECTS:
Irritant: inhalation, skin, eye
ACUTE TOXICITY LEVEL:
Slightly Toxic: ingestion
Relatively Non-toxic: dermal absorption
ADDITIONAL DATA: Interactions with drugs may occur.
SODIUM METABISULFITE:
IRRITATION DATA: 500 mg skin-rabbit; 100 mg/24 hour(s) eyes-rabbit mild
TOXICITY DATA: >1 gm/kg skin-guinea pig LD50; 1131 mg/kg oral-rat LD50
CARCINOGEN STATUS: IARC: Human Inadequate Evidence, Animal Inadequate Evidence, Group 3
(Metabisulfites); ACGIH: A4 -Not Classifiable as a Human Carcinogen
LOCAL EFFECTS:
Irritant: inhalation, skin, eye
ACUTE TOXICITY LEVEL:
Moderately Toxic: ingestion
TARGET ORGANS: immune system (sensitizer)
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: respiratory disorders
12. ECOLOGICAL INFORMATION
Not available
13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION: Not regulated.
CANADIAN TRANSPORTATION OF DANGEROUS GOODS: Not regulated.
LAND TRANSPORT ADR: Not regulated.
LAND TRANSPORT RID: Not regulated.
AIR TRANSPORT IATA: Not regulated.
AIR TRANSPORT ICAO: Not regulated.
MARITIME TRANSPORT IMDG: Not regulated.
15. REGULATORY INFORMATION
U.S. REGULATIONS:
CERCLA SECTIONS 102a/103 HAZARDOUS SUBSTANCES (40 CFR 302.4):
ACETIC ACID: 5000 LBS RQ
SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.30): Not
regulated.
SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355.40): Not
regulated.
SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370.21):
ACUTE: Yes
CHRONIC: Yes
FIRE: Yes
REACTIVE: No
SUDDEN RELEASE: No
SARA TITLE III SECTION 313 (40 CFR 372.65): Not regulated.
STATE REGULATIONS:
California Proposition 65:
Known to the state of California to cause the following:
3-Amino-9-ethylcarbazole hydrochloride
Cancer (Jul 01, 1989)
CANADIAN REGULATIONS:
WHMIS CLASSIFICATION: D2A, D2B.
EUROPEAN REGULATIONS:
EC CLASSIFICATION (CALCULATED):
Xi Irritant
DANGER/HAZARD SYMBOL:
EC RISK AND SAFETY PHRASES:
R 36/37/38 Irritating to eyes, respiratory system and skin.
S 24/25 Avoid contact with skin and eyes.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical
advice.
S 60 This material and its container must be disposed of as hazardous waste.
16. OTHER INFORMATION
EC RISK PHRASES:
R 10 Flammable.
R 22 Harmful if swallowed.
R 31 Contact with acids liberates toxic gas.
R 35 Causes severe burns.
R 36 Irritating to eyes.
R 36/37/38 Irritating to eyes, respiratory system and skin.
R 37 Irritating to respiratory system.
R 38 Irritating to skin.
R 41 Risk of serious damage to eyes.
Limitations: The information and recommendations set forth in this MSDS are believed to be correct
as of this date. Ventana Medical Systems, Inc. makes no warranty with respect to the content of this
MSDS and disclaims all liability from reliance thereon.
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