SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 17/MAY/2005
Date Updated: 25/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name SALICYLIC ACID, 99+%
Product Number W398500
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
SALICYLIC ACID FOR MANUFACTURING 69-72-7 200-712-3 None
Formula C7H6O3
Molecular Weight 138.12 AMU
Synonyms Acido o-idrossibenzoico (Italian) * Acido
salicilico (Italian) * Benzoic acid, 2-hydroxy-
* o-Hydroxybenzoic acid * 2-Hydroxybenzoic acid
* Keralyt * Kyselina 2-hydroxybenzoova (Czech) *
Kyselina salicylova (Czech) *
Orthohydroxybenzoic acid * Retarder W * SA * SAX
* Verrugon
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed. Risk of serious damage to eyes.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine crystals
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Property Value At Temperature or Pressure
pH N/A
BP/BP Range 211 掳C 20 mmHg
MP/MP Range 158 掳C
Flash Point 157 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 1 mmHg 114 掳C
SG/Density 1.44 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 4.8 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 0.1 g/ml EtOH 96% Clear
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light.
Materials to Avoid: Strong oxidizing agents, Strong bases, Iodine
Iron and iron salts.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: VO0525000
ACUTE TOXICITY
LD50
Oral
Rat
891 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle weakness.
LC50
Inhalation
Rat
> 900 mg/m3
1H
LD50
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Skin
Rat
> 2000 mg/kg
Remarks: Liver:Other changes. Skin and Appendages: Other: Hair.
LD50
Intraperitoneal
Rat
157 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Tremor. Nutritional and Gross Metabolic:Changes
in:Body temperature decrease.
LD50
Oral
Mouse
480 mg/kg
LD50
Intraperitoneal
Mouse
300 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Respiratory depression.
LD50
Intravenous
Mouse
184 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Oral
Cat
400 mg/kg
LD50
Oral
Rabbit
1300 mg/kg
LD50
Skin
Rabbit
> 10000 mg/kg
LC50
Inhalation
Mammal
> 300 mg/m3
IRRITATION DATA
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
100 mg
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Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Mild chronic salicylate intoxication is termed salicylism.
Symptoms include: headache, dizziness, ringing in the ears,
difficulty in hearing, dimness of vision, mental confusion,
lassitude, drowsiness, sweating, thirst, hyperventilation,
nausea, vomiting, and occasionally diarrhea. A more severe
degree of salicylate intoxication is characterized by more
pronounced CNS disturbances (including generalized convulsions
and coma), skin eruptions, and marked alterations in acid-base
balance.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system. Blood.
CHRONIC EXPOSURE - MUTAGEN
Mouse
100 MG/KG
Oral
DNA inhibition
ZNEG
Histidine reversion (Ames)
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1050 MG/KG
Route of Application: Oral
Exposure Time: (8-14D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 700 MG/KG
Route of Application: Oral
Exposure Time: (8-14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 350 MG/KG
Route of Application: Oral
Exposure Time: (8-14D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Mouse
Dose: 500 MG/KG
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Route of Application: Oral
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 40 MG/KG
Route of Application: Oral
Exposure Time: (20-21D PREG)
Result: Maternal Effects: Parturition.
Species: Rat
Dose: 1050 MG/KG
Route of Application: Oral
Exposure Time: (8-14D PREG)
Result: Maternal Effects: Uterus, cervix, vagina. Effects on
Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants). Effects on
Fertility: Litter size (e.g.; # fetuses per litter; measured
before birth).
Species: Rat
Dose: 380 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Mouse
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (17D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
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IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22 41
Harmful if swallowed. Risk of serious damage to eyes.
S-PHRASES: 26 39
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. Wear eye/face protection.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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