SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 25/MAY/2005
Date Updated: 21/SEP/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ERYTHROSIN B, CERTIFIED
Product Number 198269
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ERYTHROSIN B 16423-68-0 240-474-8 None
Formula C20H6I4Na2O5
Molecular Weight 879.87 AMU
Synonyms Aizen erythrosine * Aizen Food Red 3 * Calcocid
erythrosine N * Canacert erythrosine BS *
9-(o-Carboxyphenyl)-6-hydroxy-2,4,5,7-tetraiodo-3
H-xanthene-3-one disodium salt monohydrate *
Cerven kysela 51 (Czech) * Cerven potravinarska
14 (Czech) * C.I. 773 * C.I. 45430 * C.I. Acid
Red 51 * C.I. Food Red 14 * Cilefa Pink B * D&C
Red No. 3 * Dolkwal erythrosine * Dye FD and C
Red No. 3 * E 127 * EBS * Edicol Supra
Erythrosine A * Edicol Supra Erythrosin AS *
Erythrosin * Erythrosin B * Erythrosin BS *
Erythrosin B sodium salt * Erythrosine *
Erythrosine B * Erythrosine 3B * Erythrosine B
(biological stain) * Erythrosine B-FO
(biological stain) * Erythrosine bluish *
Erythrosine bluish (biological stain) *
Erythrosine BS * Erythrosine Extra * Erythrosine
Extra Bluish * Erythrosine Extra Conc. A Export
* Erythrosine Extra Pure A * Erythrosine I *
Erythrosine (indicator) * Erythrosine K-FO
(biological stain) * Erythrosine Lake *
Erythrosine sodium * Erythrosine TB *
Erythrosine TB Extra * FD and C Red 3 * FDC Red
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Hygroscopic.
8 - Exposure Controls / Personal Protection
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ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Hydrogen iodide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: LM5950000
ACUTE TOXICITY
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LD50
Oral
Rat
1840 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Intraperitoneal
Rat
300 MG/KG
LD50
Intravenous
Rat
200 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
LD50
Oral
Mouse
1264 mg/kg
LD50
Intravenous
Mouse
370 MG/KG
LD50
Intravenous
Rabbit
200 MG/KG
LD50
Oral
Gerbil
1930 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
SIGNS AND SYMPTOMS OF EXPOSURE
Large doses may cause thyroid dysfunction. To the best of our
knowledge, the chemical, physical, and toxicological properties
have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Thyroid.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Neoplastic by RTECS criteria.
Endocrine:Thyroid tumors.
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CHRONIC EXPOSURE - MUTAGEN
Human
500 MG/L
Cell Type: leukocyte
DNA inhibition
Mouse
120 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
120 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
300 MG/L
Cell Type: lung
Micronucleus test
Hamster
600 MG/L
Cell Type: fibroblast
Cytogenetic analysis
Hamster
1100 MG/L
Cell Type: lung
Cytogenetic analysis
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 482 GM/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATION)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
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IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22
Harmful if swallowed.
S-PHRASES: 36
Wear suitable protective clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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