SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 24/MAY/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name SODIUM ORTHOVANADATE, 99.98%
Product Number 450243
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
SODIUM ORTHOVANADATE 13721-39-6 237-287-9 None
Formula Na3VO4
Molecular Weight 183.91 AMU
Synonyms Sodium orthovanadate * Sodium
tetraoxovanadate(3-) * Sodium vanadate(V)
(Na3VO4) (6CI) * Sodium o-vanadate * Sodium
vanadium oxide (Na3VO4) * Trisodium
orthovanadate * Trisodium vanadate * Vanadate
(VO4(3-)), trisodium (T-4)- (9CI)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful by inhalation, in contact with skin and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL LTEL 0.05 MG(V2O5)/M3
Remarks: dust
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
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Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 850 - 866 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nature of decomposition products
not known.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: YW1120000
ACUTE TOXICITY
LD50 LD50
Oral Oral
Rat Rat
330 mg/kg 330 mg/kg
Remarks: Gastrointestinal:Hypermotility, diarrhea. Blood:
Hemorrhage. Gastrointestinal:Hypermotility, diarrhea. Blood:
Hemorrhage.
LD50 LD50
Intraperitoneal Intraperitoneal
Mouse Mouse
36300 UG/KG 36300 UG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
Vanadium compounds can cause metallic taste and a greenish
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discoloration of the tongue. Exposure can cause coughing,
wheezing, respiratory distress, and diarrhea. Gastrointestinal
disturbances. Tremors. Headache.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
CHRONIC EXPOSURE - MUTAGEN
Human Human
10 UMOL/L 10 UMOL/L
Cell Type: lymphocyte lymphocyte
Micronucleus test Micronucleus test
Human Human
20 UMOL/L 20 UMOL/L
Cell Type: lymphocyte lymphocyte
Cytogenetic analysis Cytogenetic analysis
Human Human
80 UMOL/L 80 UMOL/L
Cell Type: lymphocyte lymphocyte
Sister chromatid exchange Sister chromatid exchange
Human Human
5 UMOL/L 5 UMOL/L
Cell Type: lymphocyte lymphocyte
SLN SLN
Mouse Mouse
75 MG/KG 75 MG/KG
Oral Oral
Micronucleus test Micronucleus test
Mouse Mouse
1 MG/L 1 MG/L
Cell Type: Embryo Embryo
Morphological transformation. Morphological transformation.
Mouse Mouse
75 MG/KG 75 MG/KG
Oral Oral
Cytogenetic analysis Cytogenetic analysis
Mouse Mouse
75 MG/KG 75 MG/KG
Oral Oral
SLN SLN
Mammal Mammal
10 UMOL/L 10 UMOL/L
Cell Type: kidney kidney
Other mutation test systems Other mutation test systems
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse Mouse
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Dose: 300 MG/KG 300 MG/KG
Route of Application: Oral Oral
Exposure Time: (6-15D PREG) (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat Rat
Dose: 33750 UG/KG 33750 UG/KG
Route of Application: Oral Oral
Exposure Time: (10D PREG) (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Post-implantation mortality (e.g., dead
and/or resorbed implants per total number of implants).
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed.
S-PHRASES: 22 36
Do not breathe dust. Wear suitable protective clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
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from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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