SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/AUG/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name HEXAMETHYLENETETRAMINE,
REAGENTPLUS(TM), 99%
Product Number H11300
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
HEXAMETHYLENETETRAMINE 100-97-0 202-905-8 612-101-00-2
Formula C6H12N4
Molecular Weight 140.19 AMU
Synonyms Aceto HMT * Aminoform * Ammoform *
Ammonioformaldehyde * Cystamin * Cystogen *
Esametilentetramina (Italian) * Formamine *
Formin * Hexaform * Hexamethylenamine *
Hexamethyleneamine * Hexamethylenetetraamine *
Hexamethylentetramin (German) *
Hexamethylentetramine * Hexilmethylenamine * HMT
* Methamin * Methenamine * Preparation AF *
Resotropin * 1,3,5,7-Tetraazaadamantane *
1,3,5,7-Tetraazatricyclo(3.3.1.1(sup 37))decane
* Uritone * Urotropin * Urotropine
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. May cause sensitization by inhalation and skin
contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXPLOSION DATA
Dust Potential: This material, like most materials in powder
form, is capable of creating a dust explosion.
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable solid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Avoid raising dust. Sweep up, place in a bag and hold for waste
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid contact with eyes, skin, and
clothing. Avoid breathing dust. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
SPECIAL REQUIREMENTS: Hygroscopic.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
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GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 4 MG/M3
Poland NDSCh -
Poland NDSP -
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 3 mg/m3
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level3 mg/m3
Remarks: S
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: Colorless
Form: Crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 280 藲C
Flash Point 250 藲C Method: closed cup
Flammability N/A
Autoignition Temp 410 藲C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure < 0.01 mmHg 20 藲C
SG/Density 1.331 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:soluble
Other Solvents: ETHANOL, ACETONE, CHLOROFORM
10 - Stability and Reactivity
STABILITY
Conditions to Avoid: Moisture.
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Materials to Avoid: Strong acids, Reacts with acids liberating
formaldehyde, Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: MN4725000
ACUTE TOXICITY
LD50
Intravenous
Rat
9200 MG/KG
LD50
Oral
Mouse
569 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Muscle contraction or
spasticity.
LD50
Subcutaneous
Mouse
215 MG/KG
Remarks: Behavioral:Tremor. Gastrointestinal:Changes in
structure or function of salivary glands.
LD50
Intravenous
Mouse
17700 UL/KG
SENSITIZATION
Sensitization: May cause allergic reaction.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Subcutaneous
Exposure Time: 78W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Tumors at site or application.
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CHRONIC EXPOSURE - MUTAGEN
Human
100 UMOL/L
Cell Type: HeLa cell
Other mutation test systems
Human
1 MMOL/L
Cell Type: HeLa cell
Cytogenetic analysis
Mouse
25 GM/KG
Intraperitoneal
Dominant lethal test
Mouse
25 GM/KG
Oral
Dominant lethal test
Hamster
10 MG/L
Cell Type: kidney
Morphological transformation.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1328
Class: 4.1
PG: III
Proper Shipping Name: Hexamethylenetetramine
IMDG
UN#: 1328
Class: 4.1
PG: III
Proper Shipping Name: Hexamethylenetetramine
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1328
Class: 4.1
PG: III
Proper Shipping Name: Hexamethylenetetramine
Inhalation Packing Group I: No
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15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 612-101-00-2
INDICATION OF DANGER: F Xn
Highly Flammable. Harmful.
R-PHRASES: 11 42/43
Highly flammable. May cause sensitization by inhalation and
skin contact.
S-PHRASES: 16 22 24 37
Keep away from sources of ignition - no smoking. Do not breathe
dust. Avoid contact with skin. Wear suitable gloves.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 5
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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