Material Safety Data Sheet
Pierce?Iodination Reagent
1. Product and company identification
Pierce?Iodination Reagent
Product name :
imidazo[4,5-d]imidazole-2,5(1h,3h)-dione, 1,3,4,6-tetrachlorotetrahydro-3a,6a-diphenyl-
Synonym :
C16-H10-Cl4-N4-O2
Chemical formula :
Thermo Fisher Scientific : Thermo Fisher Scientific
Supplier : Manufacturer
Pierce Biotechnology Pierce Biotechnology
P.O. Box 117 P.O. Box 117
Rockford, IL 61105 Rockford, IL 61105
United States United States
815.968.0747 or 815.968.0747
800.874.3723 800.874.3723
0028600 1803610
Product No. :
339
MSDS # :
Validation date : 8/25/2008.
8/25/2008.
Print date :
Responsible name : MSDS (Regulatory Affairs)
CHEMTREC: Use of : Refer to the instruction booklet for
:
In case of emergency
800.424.9300 Substance/Preparation proper and intended use.
OUTSIDE US: Otherwise, contact supplier for
202.483.7616 specific applications.
2. Hazards identification
: Solid. [Powder.]
Physical state
: This material is considered hazardous by the OSHA Hazard Communication Standard
OSHA/HCS status
(29 CFR 1910.1200).
: WARNING !
Emergency overview
CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. MAY CAUSE
TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA.
Irritating to eyes, respiratory system and skin. Handling and/or processing of this
material may generate a dust which can cause mechanical irritation of the eyes, skin,
nose and throat. Avoid breathing dust. Avoid contact with eyes, skin and clothing. May
cause target organ damage, based on animal data. Use only with adequate ventilation.
Keep container tightly closed and sealed until ready for use. Wash thoroughly after
handling.
: Eye contact. Inhalation. Ingestion.
Routes of entry
Potential acute health effects
: Irritating to respiratory system. Exposure to decomposition products may cause a health
Inhalation
hazard. Serious effects may be delayed following exposure.
: No known significant effects or critical hazards.
Ingestion
: Irritating to skin.
Skin
: Irritating to eyes.
Eyes
Potential chronic health effects
: May cause target organ damage, based on animal data.
Chronic effects
: No known significant effects or critical hazards.
Carcinogenicity
: No known significant effects or critical hazards.
Mutagenicity
: No known significant effects or critical hazards.
Teratogenicity
: No known significant effects or critical hazards.
Developmental effects
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2. Hazards identification
: No known significant effects or critical hazards.
Fertility effects
: May cause damage to the following organs: kidneys, liver, central nervous system
Target organs
(CNS).
Over-exposure signs/symptoms
: Adverse symptoms may include the following:
Inhalation
respiratory tract irritation
coughing
: No specific data.
Ingestion
: Adverse symptoms may include the following:
Skin
irritation
redness
: Adverse symptoms may include the following:
Eyes
pain or irritation
watering
redness
: Pre-existing disorders involving any target organs mentioned in this MSDS as being at
Medical conditions
risk may be aggravated by over-exposure to this product.
aggravated by over-
exposure
The substance is classified as dangerous according to Directive 67/548/EEC and its amendments.
: Xi; R36/37/38
Classification
: Irritating to eyes, respiratory system and skin.
Human health hazards
See toxicological information (section 11)
3. Composition/information on ingredients
United States
Name CAS number %
Pierce?Iodination Reagent 51592-06-4 98 - 100
Europe
: Substance
Substance/preparation
Ingredient name CAS % EC number Classification
number
Pierce?Iodination Reagent 51592-06-4 98 - 100 Xi; [1]
R36/37/38
There are no ingredients or additional ingredients present which, within the current knowledge of the supplier and
in the concentrations applicable, are classified as hazardous to health or the environment and hence require
reporting in this section.
[1] Substance classified with a health or environmental hazard
[2] Substance with a workplace exposure limit
Occupational exposure limits, if available, are listed in section 8.
4. First aid measures
: Move exposed person to fresh air. If it is suspected that fumes are still present, the
Inhalation
rescuer should wear an appropriate mask or self-contained breathing apparatus. Keep
person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest
occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous
to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention.
If unconscious, place in recovery position and get medical attention immediately.
Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.
In case of inhalation of decomposition products in a fire, symptoms may be delayed.
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4. First aid measures
The exposed person may need to be kept under medical surveillance for 48 hours.
: Wash out mouth with water. Remove dentures if any. Move exposed person to fresh
Ingestion
air. Keep person warm and at rest. If material has been swallowed and the exposed
person is conscious, give small quantities of water to drink. Stop if the exposed person
feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do
so by medical personnel. If vomiting occurs, the head should be kept low so that vomit
does not enter the lungs. Get medical attention if adverse health effects persist or are
severe. Never give anything by mouth to an unconscious person. If unconscious, place
in recovery position and get medical attention immediately. Maintain an open airway.
Loosen tight clothing such as a collar, tie, belt or waistband.
: Flush contaminated skin with plenty of water. Remove contaminated clothing and
Skin contact
shoes. Continue to rinse for at least 10 minutes. Get medical attention. Wash clothing
before reuse. Clean shoes thoroughly before reuse.
: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting
Eye contact
the upper and lower eyelids. Check for and remove any contact lenses. Get medical
attention.
: No action shall be taken involving any personal risk or without suitable training. If it is
Protection of first-aiders
suspected that fumes are still present, the rescuer should wear an appropriate mask or
self-contained breathing apparatus. It may be dangerous to the person providing aid to
give mouth-to-mouth resuscitation.
See section 11 for more detailed information on health effects and symptoms.
5. Fire-fighting measures
: No specific fire or explosion hazard.
Flammability of the product
Extinguishing media
: Use an extinguishing agent suitable for the surrounding fire.
Suitable
: None known.
Not suitable
: Promptly isolate the scene by removing all persons from the vicinity of the incident if
Special exposure hazards
there is a fire. No action shall be taken involving any personal risk or without suitable
training.
: Decomposition products may include the following materials:
Hazardous combustion
carbon oxides
products
nitrogen oxides
halogenated compounds
: Fire-fighters should wear appropriate protective equipment and self-contained breathing
Special protective
apparatus (SCBA) with a full face-piece operated in positive pressure mode.
equipment for fire-fighters
6. Accidental release measures
: No action shall be taken involving any personal risk or without suitable training.
Personal precautions
Evacuate surrounding areas. Keep unnecessary and unprotected personnel from
entering. Do not touch or walk through spilled material. Avoid breathing dust. Provide
adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put
on appropriate personal protective equipment (see section 8).
: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
Environmental precautions
and sewers. Inform the relevant authorities if the product has caused environmental
pollution (sewers, waterways, soil or air).
: Move containers from spill area. Approach release from upwind. Prevent entry into
Large spill
sewers, water courses, basements or confined areas. Vacuum or sweep up material
and place in a designated, labeled waste container. Avoid creating dusty conditions and
prevent wind dispersal. Dispose of via a licensed waste disposal contractor. Note: see
section 1 for emergency contact information and section 13 for waste disposal.
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6. Accidental release measures
: Move containers from spill area. Vacuum or sweep up material and place in a
Small spill
designated, labeled waste container. Dispose of via a licensed waste disposal
contractor.
7. Handling and storage
: Put on appropriate personal protective equipment (see section 8). Eating, drinking and
Handling
smoking should be prohibited in areas where this material is handled, stored and
processed. Workers should wash hands and face before eating, drinking and smoking.
Do not breathe dust. Do not ingest. Avoid contact with eyes, skin and clothing. Use
only with adequate ventilation. Wear appropriate respirator when ventilation is
inadequate. Keep in the original container or an approved alternative made from a
compatible material, kept tightly closed when not in use. Empty containers retain
product residue and can be hazardous. Do not reuse container.
: Store between the following temperatures: 2 to 8癈 (35.6 to 46.4癋). Store in
Storage
accordance with local regulations. Store in original container protected from direct
sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see
section 10) and food and drink. Keep container tightly closed and sealed until ready for
use. Containers that have been opened must be carefully resealed and kept upright to
prevent leakage. Do not store in unlabeled containers. Use appropriate containment to
avoid environmental contamination.
8. Exposure controls/personal protection
Europe
No exposure limit value known.
Consult local authorities for acceptable exposure limits.
: If this product contains ingredients with exposure limits, personal, workplace atmosphere
Recommended monitoring
or biological monitoring may be required to determine the effectiveness of the ventilation
procedures
or other control measures and/or the necessity to use respiratory protective equipment.
: Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapor
Engineering measures
or mist, use process enclosures, local exhaust ventilation or other engineering controls
to keep worker exposure to airborne contaminants below any recommended or statutory
limits.
: Wash hands, forearms and face thoroughly after handling chemical products, before
Hygiene measures
eating, smoking and using the lavatory and at the end of the working period. Appropriate
techniques should be used to remove potentially contaminated clothing. Wash
contaminated clothing before reusing. Ensure that eyewash stations and safety showers
are close to the workstation location.
Personal protection
: Use a properly fitted, air-purifying or air-fed respirator complying with an approved
Respiratory
standard if a risk assessment indicates this is necessary. Respirator selection must be
based on known or anticipated exposure levels, the hazards of the product and the safe
working limits of the selected respirator.
: Chemical-resistant, impervious gloves complying with an approved standard should be
Hands
worn at all times when handling chemical products if a risk assessment indicates this is
necessary.
: Safety eyewear complying with an approved standard should be used when a risk
Eyes
assessment indicates this is necessary to avoid exposure to liquid splashes, mists,
gases or dusts. If operating conditions cause high dust concentrations to be produced,
use dust goggles.
: Personal protective equipment for the body should be selected based on the task being
Skin
performed and the risks involved and should be approved by a specialist before handling
this product.
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8. Exposure controls/personal protection
: Emissions from ventilation or work process equipment should be checked to ensure they
Environmental exposure
comply with the requirements of environmental protection legislation. In some cases,
controls
fume scrubbers, filters or engineering modifications to the process equipment will be
necessary to reduce emissions to acceptable levels.
9. Physical and chemical properties
Solid. [Powder.]
Physical state :
White.
Color :
432.09 g/mole
Molecular weight :
C16-H10-Cl4-N4-O2
Molecular formula :
255癈 (491癋)
Melting/freezing point :
Insoluble in the following materials: cold water and hot water.
Solubility :
10 . Stability and reactivity
: The product is stable. Under normal conditions of storage and use, hazardous
Chemical stability
polymerization will not occur.
: No specific data.
Conditions to avoid
: No specific data.
Incompatible materials
: Under normal conditions of storage and use, hazardous decomposition products should
Hazardous decomposition
not be produced.
products
: Will not occur.
Possibility of hazardous
reactions
11 . Toxicological information
United States
Acute toxicity
Product/ingredient name Result Species Dose Exposure
imidazo[4,5-d]imidazole-2,5(1h,3h)-dione, LDLo Mouse 250 mg/kg -
1,3,4,6-tetrachlorotetrahydro-3a,6a- Intraperitoneal
diphenyl-
: Not available.
Conclusion/Summary
Chronic toxicity
: Not available.
Conclusion/Summary
Carcinogenicity
: Not available.
Conclusion/Summary
Mutagenicity
: Not available.
Conclusion/Summary
Teratogenicity
: Not available.
Conclusion/Summary
Reproductive toxicity
: Not available.
Conclusion/Summary
Europe
Repeated or prolonged inhalation of dust may lead to chronic respiratory irritation.
Chronic effects :
No known significant effects or critical hazards.
Carcinogenicity :
No known significant effects or critical hazards.
Mutagenicity :
No known significant effects or critical hazards.
Teratogenicity :
No known significant effects or critical hazards.
Developmental effects :
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11 . Toxicological information
: No known significant effects or critical hazards.
Fertility effects
12 . Ecological information
: No known significant effects or critical hazards.
Environmental effects
United States
Aquatic ecotoxicity
: Not available.
Conclusion/Summary
: The products of degradation are more toxic than the product itself.
Toxicity of the products of
biodegradation
: No known significant effects or critical hazards.
Other adverse effects
13 . Disposal considerations
: The generation of waste should be avoided or minimized wherever possible. Dispose of
Waste disposal
surplus and non-recyclable products via a licensed waste disposal contractor. Disposal
of this product, solutions and any by-products should at all times comply with the
requirements of environmental protection and waste disposal legislation and any regional
local authority requirements. Avoid dispersal of spilled material and runoff and contact
with soil, waterways, drains and sewers.
: The classification of the product may meet the criteria for a hazardous waste.
Hazardous waste
Disposal should be in accordance with applicable regional, national and local laws and regulations.
Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees.
14 . Transport information
Regulatory UN number Proper shipping Classes PG*
information name
Not - - -
DOT Classification
regulated.
Not available. Not available. Not available. -
IATA-DGR Class
PG* : Packing group
15 . Regulatory information
United States
: Irritating material
HCS Classification
Target organ effects
: United States inventory (TSCA 8b): This material is listed or exempted.
U.S. Federal regulations
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No
products were found.
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean Air Act (CAA) 112 accidental release prevention: No products were found.
Clean Air Act (CAA) 112 regulated flammable substances: No products were found.
Clean Air Act (CAA) 112 regulated toxic substances: No products were found.
Canada
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15 . Regulatory information
: Class D-1B: Material causing immediate and serious toxic effects (Toxic).
WHMIS (Canada)
Class D-2B: Material causing other toxic effects (Toxic).
: CEPA Toxic substances: This material is not listed.
Canadian lists
Canadian ARET: This material is not listed.
Canadian NPRI: This material is not listed.
Alberta Designated Substances: This material is not listed.
Ontario Designated Substances: This material is not listed.
Quebec Designated Substances: This material is not listed.
: Canada inventory: This material is not listed in DSL but is listed in NDSL.
Canada inventory
EU regulations
Hazard symbol or symbols :
Irritant
: R36/37/38- Irritating to eyes, respiratory system and skin.
Risk phrases
:
International regulations
: Australia inventory (AICS): Not determined.
International lists
China inventory (IECSC): Not determined.
Korea inventory (KECI): Not determined.
Philippines inventory (PICCS): Not determined.
Japan inventory (ENCS): Not determined.
16 . Other information
: CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. MAY CAUSE
Label requirements
TARGET ORGAN DAMAGE, BASED ON ANIMAL DATA.
Hazardous Material :
Information System (U.S.A.)
2
Health
0
Flammability
0
Physical hazards
The customer is responsible for determining the PPE code for this material.
National Fire Protection :
Association (U.S.A.)
Flammability
0
2 0
Health Instability
Special
Date of printing : 8/25/2008.
: 8/25/2008.
Date of issue
Date of previous issue : No previous validation.
Version :1
Indicates information that has changed from previously issued version.
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16 . Other information
: R36/37/38- Irritating to eyes, respiratory system and skin.
Full text of R-phrases
referred to in sections 2 and
3 - Europe
: Xi - Irritant
Full text of classifications
referred to in sections 2 and
3 - Europe
Notice to reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.
This product has been classified according to the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
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