Print Date: 1/04/07
ACC# 94201
Revision Date: 1/04/2007
Version: 1
Material Safety Data Sheet
Hematoxylin 7211
Section 1 - Chemical Product and Company Identification
MSDS Name:
Hematoxylin 7211
Catalog Numbers:
7211
Synonyms:
None Known.
Company Identification:
Richard Allan Scientific
4481 Campus Drive
Kalamazoo, MI 49008
Company Phone Number:
800-522-7270
Emergency Phone Number:
800-424-9300
CHEMTREC Phone Number, US:
(800) 424-9300
CHEMTREC Phone Number, Europe:
(202) 483-7616
Section 2 - Composition, Information on Ingredients
EINECS/
CAS# Chemical Name: Hazard Risk Phrases
Percent ELINCS
Symbols
107-21-1 Ethylene glycol 20-25 203-473-3
15710-63-1 Aluminum ammonium sulfate 1-5 Not available
64-19-7 Acetic acid 1-2 200-580-7
517-28-2 Hematoxylin 0.33 208-237-3
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: Purple liquid
Warning! Causes eye, skin, and respiratory tract irritation. May be harmful if
swallowed or absorbed through the skin. May cause kidney damage. May cause
central nervous system effects. Flash Point: > 200癋.
Target Organs: Kidneys, Central nervous system, Eyes, Skin, Mucous membranes
Potential Health Effects
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Print Date: 1/04/07
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Revision Date: 1/04/2007
Version: 1
Material Safety Data Sheet
Hematoxylin 7211
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon
re-exposure to this material. May be harmful if absorbed through the skin.
Ingestion:
The lethal dose in adult humans for ethylene glycol is about 100 ml (1/3 cup). Swallowing may cause
nausea, vomiting or diarrhea. Excessive exposure may cause CNS effects, cardiopulmonary effects
(metabolic acidosis), and kidney failure.
Inhalation:
Causes respiratory tract irritation. May cause effects similar to those described for ingestion. If ethylene
glycol is heated or misted in work areas that are poorly ventilated, vapor/mist may accumulate and cause
respiratory irritation and symptoms such as headache and nausea.
Chronic:
May cause kidney injury. Acetic acid can cause occupational asthma. One case of a delayed asthmatic
response to glacial acetic acid has been reported in a person with bronchial asthma. Skin sensitization to
acetic acid is rare, but has occurred. Repeated excessive exposure to ethylene glycol may cause irritation
of the upper respiratory tract. In humans, effects have been reported on the central nervous system,
including nystagmus (involuntary, rapid, rhythmic movement of the eyeball).
Section 4 - First Aid Measures
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower
eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give
anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or
equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by
thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
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Print Date: 1/04/07
ACC# 94201
Revision Date: 1/04/2007
Version: 1
Material Safety Data Sheet
Hematoxylin 7211
Autoignition Temperature:
Not applicable.
Explosion Limits:
Lower: Not available Upper: Not available
Flash Point:
> 200癋 (> 93.33癈)
NFPA Rating:
(estimated) Health: 2; Flammability: 1; Instability: 0
Section 6 - Accidental Release Measures
General Information:
Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid
runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing
precautions in the Protective Equipment section. Provide ventilation.
Section 7 - Handling and Storage
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with
adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid
ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible
substances.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible
exposure limits.
Exposure Limits
Chemical Name: ACGIH NIOSH OSHA
100 mg/m3 Ceiling None listed None listed
Ethylene glycol
(aerosol only)
Aluminum ammonium sulfate None listed None listed None listed
10 ppm TWA;15 ppm 10 ppm TWA; 25 10 ppm TWA; 25
Acetic acid
STEL mg/m3 TWA 50 ppm mg/m3 TWA;
IDLH
None listed None listed None listed
Hematoxylin
OSHA Vacated PELs
Acetic acid: 10 ppm TWA; 25 mg/m3 TWA
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Print Date: 1/04/07
ACC# 94201
Revision Date: 1/04/2007
Version: 1
Material Safety Data Sheet
Hematoxylin 7211
Personal Protective Equipment
Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Liquid
Color: Purple
Odor: Faint sweet odor
pH: No information found
Vapor Pressure: 32 mm Hg
Vapor Density: 1.1 (Air=1)
Evaporation Rate: 0.3 (Butyl acetate=1)
Viscosity: No information found
Boiling Point: 98.3-158.9癈
Freezing/Melting Point: No information found
Decomposition Temperature: No information found
Solubility in water: Soluble.
Specific Gravity/Density: 1.052 @ 21癈
Molecular Formula: Solution
Molecular Weight: No information found
Section 10 - Stability and Reactivity
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials
Incompatibilities with Other Materials
Strong oxidizing agents, strong acids, isocyanates, aliphatic amines, caustics
Hazardous Decomposition Products
Carbon monoxide, oxides of sulfur, carbon dioxide, aluminum oxide
Hazardous Polymerization
Has not been reported.
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Print Date: 1/04/07
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Revision Date: 1/04/2007
Version: 1
Material Safety Data Sheet
Hematoxylin 7211
Section 11 - Toxicological Information
RTECS:
CAS# 107-21-1: KW2975000
CAS# 15710-63-1 unlisted
CAS# 64-19-7: AF1225000
CAS# 517-28-2: MH7875000
LD50/LC50:
CAS# 107-21-1:
Draize test, rabbit, eye: 500 mg/24H Mild
Draize test, rabbit, eye: 100 mg/1H Mild
Draize test, rabbit, eye: 0.012 ppm/3D
Draize test, rabbit, eye: 1440 mg/6H Moderate
Oral, mouse: LD50 = 5500 mg/kg
Oral, rat: LD50 = 4700 mg/kg
Skin, rabbit: LD50 = 9530 uL/kg.
CAS# 15710-63-1:
No information found
CAS# 64-19-7:
Draize test, rabbit, skin: 50 mg/24H Mild
Inhalation, mouse: LC50 = 5620 ppm/1H
Oral, rat: LD50 = 3310 mg/kg
Skin, rabbit: LD50 = 1060 uL/kg.
CAS# 517-28-2:
No information found
Carcinogenicity:
CAS# 107-21-1: Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 15710-63-1: Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 64-19-7: Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 517-28-2: Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
No information available.
Teratogenicity:
An expert panel convened by the NTP's Center for the Evaluation of Risks to Human Reproduction
concluded 2/13/03 that developmental and reproductive risks stemming from exposure to the chemicals
propylene glycol and ethylene glycol are negligible.No teratogenic effects were observed among the
offspring of mice, rats, or rabbits that had been given very large doses of apple cider vinegar (containing
acetic acid) during pregnancy.Acetic acid treatment of suckling rats (via maternal administration) was
associated with abnormalities of behavioral testing.
Reproductive:
Acetic acid effects on Fertility: male index, itt-rat TDLo=400 mg/kg.
Mutagenicity:
Sister Chromatid Exchange: Human, Lymphocyte = 5 mmol/L.; Unscheduled DNA Synthesis:
Administration onto the skin, mouse = 79279 ug/kg.; Cytogenetic Analysis: Hamster, Ovary = 10 mmol/L.
Neurotoxicity:
No information available.
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Print Date: 1/04/07
ACC# 94201
Revision Date: 1/04/2007
Version: 1
Material Safety Data Sheet
Hematoxylin 7211
Other:
See actual entry in RTECS for complete information.
Section 12 - Ecological Information
No information found
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous
waste. US EPA guidelines for the classification determination are listed in 40 CFR Part 261.3. Additionally,
waste generators must consult state and local hazardous waste regulations to ensure complete and
accurate classification.
RCRA P Series Wastes
None of the components are on this list.
RCRA U Series Wastes
None of the components are on this list.
Section 14 - Transport Information
US DOT Canadian TDG
Proper Shipping Not Regulated Not Regulated
Name:
Hazard Class:
UN Number:
Packing Group:
USA RQ: CAS# 107-21-1: 5000 lb final RQ; 2270 kg final RQ
USA RQ: CAS# 64-19-7: 5000 lb final RQ; 2270 kg final RQ
Section 15 - Regulatory Information
US Federal
TSCA
CAS# 107-21-1 is listed on the TSCA Inventory.
CAS# 15710-63-1 is not listed on the TSCA Inventory. It is for research and development use only.
CAS# 64-19-7 is listed on the TSCA Inventory.
CAS# 517-28-2 is listed on the TSCA Inventory.
Health and Safety Reporting List
None of the components are on this list.
Chemical Test Rules
None of the components are on this list.
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Print Date: 1/04/07
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Revision Date: 1/04/2007
Version: 1
Material Safety Data Sheet
Hematoxylin 7211
TSCA Section 12b
None of the components are on this list.
TSCA Significant New Use Rule (SNUR)
None of the components are on this list.
CERCLA Hazardous Substances and corresponding RQs
CAS# 107-21-1: 5000 lb final RQ; 2270 kg final RQ
CAS# 64-19-7: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the components are on this list.
SARA Hazard Categories
CAS# 107-21-1: immediate, delayed.
CAS# 64-19-7: immediate, delayed, fire.
SARA Section 313
This material contains Ethylene glycol (CAS# 107-21-1, 20-25%), which is subject to the reporting
requirements of Section 313 of SARA Title III and 40 CFR Part 372.
Clean Air Act - Hazardous Air Pollutants (HAPs)
CAS# 107-21-1 is listed as a hazardous air pollutant (HAP).
Clean Air Act - Class 1 Ozone Depletors
None of the components are on this list.
Clean Air Act - Class 2 Ozone Depletors
None of the components are on this list.
Clean Water Act - Hazardous Substances
CAS# 64-19-7 is listed as a Hazardous Substance under the CWA.
Clean Water Act - Priority Pollutants
None of the components are on this list.
Clean Water Act - Toxic Pollutants
None of the components are on this list.
OSHA - Highly Hazardous
None of the components are on this list.
OSHA - Specifically Regulated Chemicals
None of the components are on this list.
US State
State Right to Know
Ethylene glycol can be found on the following state Right-to-Know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
Acetic acid can be found on the following state Right-to-Know lists: California, New Jersey, Pennsylvania,
Minnesota, Massachusetts.
No information found
California Prop 65
None of the components are on this list.
California No Significant Risk Level
None of the components are on this list.
None of the components are on this list.
None of the components are on this list.
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Print Date: 1/04/07
ACC# 94201
Revision Date: 1/04/2007
Version: 1
Material Safety Data Sheet
Hematoxylin 7211
None of the components are on this list.
European/International Regulations
European Labelling in Accordance with EC Directives:
Hazard Symbols: XN
Risk Phrases: R 22 Harmful if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases: S 23 Do not inhale gas/fumes/vapour/spray.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
No information found
United Kingdom Occupational Exposure Limits
No information found
United Kingdom Maximum Exposure Limits
No information found
Canadian DSL/NDSL
CAS# 107-21-1 is listed on Canada's DSL List.
CAS# 15710-63-1 is listed on Canada's DSL List.
CAS# 64-19-7 is listed on Canada's DSL List.
CAS# 517-28-2 is listed on Canada's DSL List.
Canadian WHMIS Classifications
This product has a WHMIS classification of D1B, D2B.
This product has been classified in accordance with the hazard criteria of the Controlled Products
Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
CAS# 107-21-1 is listed on the Canadian Ingredient Disclosure List.
CAS# 64-19-7 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Other Information
Color information has been
MSDS Creation Date: January 4, 2007
Revision Date: January 4, 2007
Revisions were made in Sections:
14
This MSDS is intended for review and guidance in the receipt, storage, handling, use and disposal of product purchased
from us, and for no other purpose. Use this product only as directed and in accordance with applicable instructions and
warnings provided with the product. Please consult your institution's policies regarding use of this product. If you have
obtained this MSDS other than in connection with the supply of this product from us, this MSDS should be consulted for
general information only, and should not be relied upon for any purpose. As with the use of all hazardous materials, you
should in all instances follow the guidance of the MSDS provided or available with the specific product purchased.
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