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 Methylene Blue Solution (Loeffer)

Section 1 - Chemical Product and Company Identification

MSDS Name: Methylene Blue Solution (Loeffer)
Catalog Numbers: S80083
Company Identification:

              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call:
Emergency Number:
For CHEMTREC assistance, call:
For International CHEMTREC assistance, call:

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
7732-18-5 Water 80.0 231-791-2
67-56-1 Methyl alcohol 19.0 200-659-6
61-73-4 Methylene blue 0.23 200-515-2

Section 3 - Hazards Identification


Appearance: clear blue liquid. Flash Point: 41.7 deg C.
Warning! Flammable liquid and vapor. Causes eye, skin, and respiratory tract irritation. May be absorbed through intact skin. May cause central nervous system depression. This substance has caused adverse reproductive and fetal effects in animals. May cause liver and kidney damage. May cause blindness if swallowed. Cannot be made non-poisonous.
Target Organs: Kidneys, central nervous system, liver.

Potential Health Effects
Eye: Causes eye irritation. May cause painful sensitization to light.
Skin: May cause skin irritation. May be absorbed through the skin.
Ingestion: May be fatal or cause blindness if swallowed. May cause irritation of the digestive tract. May cause kidney failure.
Inhalation: May cause respiratory tract irritation. May cause adverse central nervous system effects including headache, convulsions, and possible death. May cause visual impairment and possible permanent blindness. May cause effects similar to those described for ingestion.
Chronic: Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.

Section 4 - First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: Get medical aid. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors can travel to a source of ignition and flash back. Flammable Liquid. Can release vapors that form explosive mixtures at temperatures above the flashpoint.
Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam.
Flash Point: 41.7 deg C ( 107.06 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: ; Flammability: ; Instability:

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Water none listed none listed none listed
Methyl alcohol 200 ppm TWA; 250 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute 200 ppm TWA; 260 mg/m3 TWA 6000 ppm IDLH 200 ppm TWA; 260 mg/m3 TWA
Methylene blue none listed none listed none listed

OSHA Vacated PELs: Water: No OSHA Vacated PELs are listed for this chemical. Methyl alcohol: 200 ppm TWA; 260 mg/m3 TWA Methylene blue: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: clear blue
Odor: alcohol odor.
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Completely soluble in water.
Specific Gravity/Density:Not available.
Molecular Formula:Mixture
Molecular Weight:Not available.

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: High temperatures, incompatible materials, ignition sources.
Incompatibilities with Other Materials: Methanol is incompatible with oxidants (such as barium perchlorate, bromine, chlorine, hydrogen peroxide, lead perchlorate, perchloric acid, sodium hypochlorite). Active metals (such as potassium and magnesium). Substance is also incompatible with specific chemicals including: acetyl bromide, alkyl aluminum salts, beryllium dihydride, carbon tetrachloride + metals, chloroform + heat, chloroform + sodium hydroxide, cyanuric chloride, diethyl zinc, nitric acid, and potassium tertbutoxide. Please refer to the NFPA Fire Protection Guide for all specifics.
Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, formaldehyde.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

CAS# 7732-18-5: ZC0110000      
CAS# 67-56-1: PC1400000      
CAS# 61-73-4: SO5600000
CAS# 7732-18-5:
     Oral, rat: LD50 = >90 mL/kg;

CAS# 67-56-1:
     Draize test, rabbit, eye: 40 mg Moderate;
     Draize test, rabbit, eye: 100 mg/24H Moderate;
     Draize test, rabbit, skin: 20 mg/24H Moderate;
     Inhalation, rabbit: LC50 = 81000 mg/m3/14H;
     Inhalation, rat: LC50 = 64000 ppm/4H;
     Oral, mouse: LD50 = 7300 mg/kg;
     Oral, rabbit: LD50 = 14200 mg/kg;
     Oral, rat: LD50 = 5600 mg/kg;
     Skin, rabbit: LD50 = 15800 mg/kg;

CAS# 61-73-4:
     Oral, mouse: LD50 = 3500 mg/kg;
     Oral, rat: LD50 = 1180 mg/kg;

CAS# 7732-18-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 67-56-1: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 61-73-4: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information available.
Teratogenicity: Methanol effects on Newborn: behaviorial, orl-rat TDLo=7500 mg/kg. Embryo or Fetus: fetotoxicity, TCLo=10000 ppm/7H Specific Developmental Abnormalities: cardiovascular, musculoskeletal, urogenital, TCLo=20000 ppm/7H.
Reproductive Effects: Methanol Paternal Effects: spermatogenesis, ipr-mouse TDLo=5 g/kg.
Mutagenicity: Methanol DNA Damage: orl-rat 10 umol/kg. methanol DNA Inhibition: human lymphocyte 300 mmol/L. Microbial Mutation w/o S9: S. cerevisiae 12 pph.
Neurotoxicity: No information available.
Other Studies:

Section 12 - Ecological Information

No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 67-56-1: waste number U154 (Ignitable waste).

Section 14 - Transport Information

Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S. No information available.
Hazard Class: 3
UN Number: UN2924
Packing Group: II

Section 15 - Regulatory Information


     CAS# 7732-18-5 is listed on the TSCA inventory.
     CAS# 67-56-1 is listed on the TSCA inventory.
     CAS# 61-73-4 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 67-56-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 67-56-1: immediate, fire.
     CAS # 61-73-4: immediate, delayed.
Section 313
     This material contains Methyl alcohol (CAS# 67-56-1, 19.0%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
     CAS# 67-56-1 is listed as a hazardous air pollutant (HAP).

     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
     None of the chemicals in this product are considered highly hazardous by OSHA.
     CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ.
     CAS# 67-56-1 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 61-73-4 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
      Not available.
Risk Phrases:

     R 11 Highly flammable.
     R 23/25 Toxic by inhalation and if swallowed.

Safety Phrases:

     S 16 Keep away from sources of ignition - No smoking.
     S 2 Keep out of reach of children.
     S 24 Avoid contact with skin.
     S 7 Keep container tightly closed.

WGK (Water Danger/Protection)

     CAS# 7732-18-5: No information available.
     CAS# 67-56-1: 1
     CAS# 61-73-4: 2
Canada - DSL/NDSL
     CAS# 7732-18-5 is listed on Canada's DSL List.
     CAS# 67-56-1 is listed on Canada's DSL List.
     CAS# 61-73-4 is listed on Canada's DSL List.
Canada - WHMIS
     not available.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 67-56-1 is listed on the Canadian Ingredient Disclosure List.
     CAS# 61-73-4 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 9/02/1997
Revision #5 Date: 2/15/2008

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.

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