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MSDS  
:
 Cis-1,2-Dihydro-3-Methylcatechol, 20w/v % Soln. in Ethyl Acetate, Stab. with 0.2% TEA
CAS  
:
 25506-13-2
SYNONYMS  
:
 Cis-1,2-Dihydroxy-3-Methylcyclohexa-3,5-Diene.

Section 1 - Chemical Product and Company Identification
MSDS Name: Cis-1,2-Dihydro-3-Methylcatechol, 20w/v % Soln. in Ethyl Acetate, Stab. with 0.2% TEA
Catalog Numbers: AC296830000, AC296830050
Synonyms:
Cis-1,2-Dihydroxy-3-Methylcyclohexa-3,5-Diene.
Company Identification:

              Acros Organics N.V.
              One Reagent Lane
              Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
141-78-6 Ethyl acetate 80 205-500-4
25506-13-2 Cis-1,2-Dihydro-3-Methylcatechol 20 unlisted

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: clear brown liquid. Flash Point: -4 deg C.
Warning! Flammable liquid and vapor. Causes eye irritation. May be harmful if inhaled. May cause skin and respiratory tract irritation. May cause central nervous system depression. May cause liver and kidney damage.
Target Organs: Kidneys, central nervous system, liver.


Potential Health Effects
Eye: Causes eye irritation. Vapors may cause eye irritation.
Skin: May cause skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
Ingestion: May cause irritation of the digestive tract. May cause liver and kidney damage. Ingestion of large amounts may cause central nervous depression. May cause headache, nausea, fatigue, and dizziness.
Inhalation: May cause respiratory tract irritation. Inhalation of high concentrations may cause narcotic effects. May be harmful if inhaled.
Chronic: Chronic inhalation may cause effects similar to those of acute inhalation. Chronic exposure may produce anemia, leukocytosis, cloudy swelling, and fatty degeneration of the viscera.

Section 4 - First Aid Measures


Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Flammable Liquid. Can release vapors that form explosive mixtures at temperatures above the flashpoint. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Containers may explode in the heat of a fire. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out. Do not use bicarbonate based dry chemical extinguishers for fires involving nitromethane or nitroethanes. Reaction with alkaline bicarbonates or other strong alkalis can form salts that may reignite when dry.
Flash Point: -4 deg C ( 24.80 deg F)
Autoignition Temperature: Not available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 1; Flammability: 3; Instability: 0

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Use with adequate ventilation. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.)

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Ethyl acetate 400 ppm TWA 400 ppm TWA; 1400 mg/m3 TWA 2000 ppm IDLH 400 ppm TWA; 1400 mg/m3 TWA
Cis-1,2-Dihydro-3-Methylcatechol none listed none listed none listed

OSHA Vacated PELs: Ethyl acetate: 400 ppm TWA; 1400 mg/m3 TWA Cis-1,2-Dihydro-3-Methylcatechol: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - Physical and Chemical Properties


Physical State: Liquid
Appearance: clear brown
Odor: acetic odor
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: >1.0
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:Not available.
Decomposition Temperature:Not available.
Solubility: Not available.
Specific Gravity/Density:.9460g/cm3
Molecular Formula:C7H10O2
Molecular Weight:126.16

Section 10 - Stability and Reactivity


Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid: High temperatures, incompatible materials, ignition sources, excess heat, strong oxidants.
Incompatibilities with Other Materials: Chlorosulfonic acid, lithium aluminum hydride + 2-chloromethylfuran, lithium tetrahydroaluminate, oleum, potassium t-butoxide. Substance coming in contact with nitrates or strong acids/oxidizers/alkalies may cause fire.
Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information


RTECS#:      
CAS# 141-78-6: AH5425000      
CAS# 25506-13-2 unlisted.
LD50/LC50:
CAS# 141-78-6:
     Inhalation, mouse: LC50 = 45 gm/m3/2H;
     Inhalation, rat: LC50 = 200 gm/m3;
     Oral, mouse: LD50 = 4100 mg/kg;
     Oral, rabbit: LD50 = 4935 mg/kg;
     Oral, rat: LD50 = 5620 mg/kg;
     Skin, rabbit: LD50 = >20 mL/kg;
.

CAS# 25506-13-2:
.

Carcinogenicity:
CAS# 141-78-6: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
CAS# 25506-13-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: No information available.
Teratogenicity: No information available.
Reproductive Effects: No information available.
Mutagenicity: Cytogenetic Analysis: hamster fibroblast 9g/L. Sex Chromosome Loss/Non-disjunction: S. cerevisiae 24400 ppm.
Neurotoxicity: No information available.
Other Studies:

Section 12 - Ecological Information


Ecotoxicity: Fish: Fathead Minnow: 230mg/L; 96H; Daphnid LC50=2500 mg/L/96H Golden orfe LC50=270 mg/L/48H
Environmental: Terrestrial: Expected to have high mobility in soil. Volatilization of ethyl acetate from moist soil surfaces is expected to be important. Aquatic: Not expected to adsorb to suspended solids and sediment in water. Atmospheric: Expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 10 days.
Physical: Substance biodegrades at a high rate with little bioconcentration.
Other: For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series:
CAS# 141-78-6: waste number U112 (Ignitable waste).

Section 14 - Transport Information

US DOT Canada TDG
Shipping Name: DOT regulated - small quantity provisions apply (see 49CFR173.4) No information available.
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 141-78-6 is listed on the TSCA inventory.
     CAS# 25506-13-2 is not listed on the TSCA inventory. It is for research and development use only.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     CAS# 141-78-6: 40 CFR 799.5000
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     CAS# 141-78-6: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
SARA Codes
     CAS # 141-78-6: fire.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 141-78-6 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
     CAS# 25506-13-2 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations

European Labeling in Accordance with EC Directives
Hazard Symbols:
     F
Risk Phrases:

     R 11 Highly flammable.

Safety Phrases:

     S 16 Keep away from sources of ignition - No smoking.
     S 23 Do not inhale gas/fumes/vapour/spray.
     S 29 Do not empty into drains.
     S 33 Take precautionary measures against static discharges.

WGK (Water Danger/Protection)

     CAS# 141-78-6: 1
     CAS# 25506-13-2: No information available.
Canada - DSL/NDSL
     CAS# 141-78-6 is listed on Canada's DSL List.
Canada - WHMIS
     This product has a WHMIS classification of B2.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
     CAS# 141-78-6 is listed on the Canadian Ingredient Disclosure List.

Section 16 - Additional Information

MSDS Creation Date: 9/02/1997
Revision #8 Date: 3/15/2007

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.

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