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CAS Properties

MSDS  
: 2'-deoxy-8-hydroxyguanosine
CAS  :
SYNONYMS  : 2'-deoxy-8-hydroxyguanosine
8-OH-dG
8-OHdG compound
8-hydroxy-2'-deoxyguanosine
8-hydroxydeoxyguanosine
8-oxodGuo
C040791

  
MSDS LIST:
  • MSDS N/A The Industrial Chemicals (Notification and Assessment) Act 1989 (the Act) commenced on 17 July 1990. As required by section 5 of the Act, a Chemical Gazette is published on the first Tuesday in any month or on any days prescribed by the regulations.
    skin irritant in rabbits. TBEC, is not a skin sensitiser in guinea pigs. TBEC, in a repeat dose oral toxicity study in rats, exhibited treatment related changes to the stomach mucosa at 1 000 and 550 mg/kg/day. The NOAEL was established at 150 mg/kg/day based on the absence of treatment related effects at this dose. The notified chemical displayed mutagenic activity in a bacterial reverse mutation assay, but TBEC exhibited no genotoxic activity in vivo in a mouse micronucleus test. TBEC was investigated in a four week repeat dose dermal study for its ability to produce DNA damage and sustained epidermal hyperplasia in mouse skin. It increased dermal cellularity, however, there was no significant increase in induction of 8-OH-dG, Ha-ras mutations or epidermal hyperplasia. It was considered that this finding in isolation is an insufficient index of carcinogenic potential. Based on the data supplied the notified chemical would not be classified as a hazardous substance under the NOHSC...
    http://www.chemcas.org/msds113/supplier/cas/0/1923593389.asp
  • MSDS N/A The Industrial Chemicals (Notification and Assessment) Act 1989 (the Act) commenced on 17 July 1990. As required by section 5 of the Act, a Chemical Gazette is published on the first Tuesday in any month or on any days prescribed by the regulations.
    skin irritant in rabbits. TBEC, is not a skin sensitiser in guinea pigs. TBEC, in a repeat dose oral toxicity study in rats, exhibited treatment related changes to the stomach mucosa at 1 000 and 550 mg/kg/day. The NOAEL was established at 150 mg/kg/day based on the absence of treatment related effects at this dose. The notified chemical displayed mutagenic activity in a bacterial reverse mutation assay, but TBEC exhibited no genotoxic activity in vivo in a mouse micronucleus test. TBEC was investigated in a four week repeat dose dermal study for its ability to produce DNA damage and sustained epidermal hyperplasia in mouse skin. It increased dermal cellularity, however, there was no significant increase in induction of 8-OH-dG, Ha-ras mutations or epidermal hyperplasia. It was considered that this finding in isolation is an insufficient index of carcinogenic potential. Based on the data supplied the notified chemical would not be classified as a hazardous substance under the NOHSC...
    http://www.chemcas.org/msds113/supplier/cas/1/1433618538.asp
  • MSDS N/A The Industrial Chemicals (Notification and Assessment) Act 1989 (the Act) commenced on 17 July 1990. As required by section 5 of the Act, a Chemical Gazette is published on the first Tuesday in any month or on any days prescribed by the regulations.
    skin irritant in rabbits. TBEC, is not a skin sensitiser in guinea pigs. TBEC, in a repeat dose oral toxicity study in rats, exhibited treatment related changes to the stomach mucosa at 1 000 and 550 mg/kg/day. The NOAEL was established at 150 mg/kg/day based on the absence of treatment related effects at this dose. The notified chemical displayed mutagenic activity in a bacterial reverse mutation assay, but TBEC exhibited no genotoxic activity in vivo in a mouse micronucleus test. TBEC was investigated in a four week repeat dose dermal study for its ability to produce DNA damage and sustained epidermal hyperplasia in mouse skin. It increased dermal cellularity, however, there was no significant increase in induction of 8-OH-dG, Ha-ras mutations or epidermal hyperplasia. It was considered that this finding in isolation is an insufficient index of carcinogenic potential. Based on the data supplied the notified chemical would not be classified as a hazardous substance under the NOHSC...
    http://www.chemcas.org/msds113/supplier/cas/3/1433618538.asp
  • MSDS N/A The Industrial Chemicals (Notification and Assessment) Act 1989 (the Act) commenced on 17 July 1990. As required by section 5 of the Act, a Chemical Gazette is published on the first Tuesday in any month or on any days prescribed by the regulations.
    skin irritant in rabbits. TBEC, is not a skin sensitiser in guinea pigs. TBEC, in a repeat dose oral toxicity study in rats, exhibited treatment related changes to the stomach mucosa at 1 000 and 550 mg/kg/day. The NOAEL was established at 150 mg/kg/day based on the absence of treatment related effects at this dose. The notified chemical displayed mutagenic activity in a bacterial reverse mutation assay, but TBEC exhibited no genotoxic activity in vivo in a mouse micronucleus test. TBEC was investigated in a four week repeat dose dermal study for its ability to produce DNA damage and sustained epidermal hyperplasia in mouse skin. It increased dermal cellularity, however, there was no significant increase in induction of 8-OH-dG, Ha-ras mutations or epidermal hyperplasia. It was considered that this finding in isolation is an insufficient index of carcinogenic potential. Based on the data supplied the notified chemical would not be classified as a hazardous substance under the NOHSC...
    http://www.chemcas.org/msds113/supplier/cas/5/1433618538.asp
  • MSDS N/A The Industrial Chemicals (Notification and Assessment) Act 1989 (the Act) commenced on 17 July 1990. As required by section 5 of the Act, a Chemical Gazette is published on the first Tuesday in any month or on any days prescribed by the regulations.
    skin irritant in rabbits. TBEC, is not a skin sensitiser in guinea pigs. TBEC, in a repeat dose oral toxicity study in rats, exhibited treatment related changes to the stomach mucosa at 1 000 and 550 mg/kg/day. The NOAEL was established at 150 mg/kg/day based on the absence of treatment related effects at this dose. The notified chemical displayed mutagenic activity in a bacterial reverse mutation assay, but TBEC exhibited no genotoxic activity in vivo in a mouse micronucleus test. TBEC was investigated in a four week repeat dose dermal study for its ability to produce DNA damage and sustained epidermal hyperplasia in mouse skin. It increased dermal cellularity, however, there was no significant increase in induction of 8-OH-dG, Ha-ras mutations or epidermal hyperplasia. It was considered that this finding in isolation is an insufficient index of carcinogenic potential. Based on the data supplied the notified chemical would not be classified as a hazardous substance under the NOHSC...
    http://www.chemcas.org/msds113/supplier/cas/6/1433618538.asp
  • MSDS 88847-89-6 54827-17-7 26628-22-8 7722-84-1 9005-64-5 7664-38-2
    temperature. Hazardous decomposition products: Nitrogen oxides, nitrogen gas and sodium compounds. Hazardous polymerization: Will not occur. SECTION V - HEALTH HAZARD 3,3',5,5'-Tetramethylbenzidine (TMB): Threshold limit value: N/A Toxicity data: ORL-QAL LD50: >316 MG/KG. The toxicological properties of this material have not been thoroughly investigated. Health hazards: May be harmful by inhalation, ingestion, or skin absorption. Causes skin irritation. may be harmful if absorbed through the skin. Causes eye irritation. Irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. May be harmful if swallowed. First aid procedures: If swallowed seek immediate medical attention. In case of contact with eyes or skin, flush with plenty of water and seek medical attention. If inhaled, expose to fresh air and seek medical attention. 8-Hydroxy-2'-deoxyguanosine: Threshold limit value: None established Toxicity data: The toxicological properties of this compound have...
    http://www.chemcas.org/msds114/supplier/cas/760/88847-89-6_54827-17-7_26628-22-8_7722-84-1_9005-64-5_7664-38.asp
  • MSDS 88847-89-6 54827-17-7 26628-22-8 7722-84-1 9005-64-5 7664-38-2
    temperature. Hazardous decomposition products: Nitrogen oxides, nitrogen gas and sodium compounds. Hazardous polymerization: Will not occur. SECTION V - HEALTH HAZARD 3,3',5,5'-Tetramethylbenzidine (TMB): Threshold limit value: N/A Toxicity data: ORL-QAL LD50: >316 MG/KG. The toxicological properties of this material have not been thoroughly investigated. Health hazards: May be harmful by inhalation, ingestion, or skin absorption. Causes skin irritation. may be harmful if absorbed through the skin. Causes eye irritation. Irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. May be harmful if swallowed. First aid procedures: If swallowed seek immediate medical attention. In case of contact with eyes or skin, flush with plenty of water and seek medical attention. If inhaled, expose to fresh air and seek medical attention. 8-Hydroxy-2'-deoxyguanosine: Threshold limit value: None established Toxicity data: The toxicological properties of this compound have...
    http://www.chemcas.org/msds114/supplier/cas/90/88847-89-6_54827-17-7_26628-22-8_7722-84-1_9005-64-5_7664-38.asp
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    NI NI
    SO4 SO4
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